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10.3389/fimmu.2017.00600 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00600 C5442166!5442166!28596771     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28596771|t=2017. Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans |pdf=|usr=}}{{28596771}} gab.com Text Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28596771 #FOAvip Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate extravasation into non-lymphoid tissues. The capacity for T cells to interact with all of these selectins is dependent on the enzymatic synthesis of complex O-glycans, and thus, this protein modification plays an indispensable role in regulating the distribution and homing of both naive and previously activated T cells in vivo. In contrast to neutrophils, O-glycan synthesis is highly dynamic in T cell populations and is largely controlled by extracellular stimuli such as antigen recognition or signaling though cytokine receptors. Herein, we review the basic principles of enzymatic synthesis of complex O-glycans, discuss tools and reagents for studying this type of protein modification and highlight our current understanding of how O-glycan synthesis is regulated and subsequently impacts the trafficking potential of diverse T cell populations. Twit Text FOAVip Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28596771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28596771 #FOAvip English Wikipedia <ref>{{Cite pmid|28596771}}</ref> Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans #MMPMID28596771 Hobbs SJ; Nolz JC Front Immunol 2017[]; 8 (ä): ä PMID28596771show ga Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate extravasation into non-lymphoid tissues. The capacity for T cells to interact with all of these selectins is dependent on the enzymatic synthesis of complex O-glycans, and thus, this protein modification plays an indispensable role in regulating the distribution and homing of both naive and previously activated T cells in vivo. In contrast to neutrophils, O-glycan synthesis is highly dynamic in T cell populations and is largely controlled by extracellular stimuli such as antigen recognition or signaling though cytokine receptors. Herein, we review the basic principles of enzymatic synthesis of complex O-glycans, discuss tools and reagents for studying this type of protein modification and highlight our current understanding of how O-glycan synthesis is regulated and subsequently impacts the trafficking potential of diverse T cell populations. äRegulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans (epmc).pdf DeepDyve Pubget Overpricing