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10.1038/s41598-017-02210-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-02210-4 C5442123!5442123 !28536464     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28536464 &cmd=llinks): Failed to open stream: HTTP request failed! 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The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A |pdf=|usr=}}{{28536464 }} gab.com Text The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536464 #FOAvip Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC. However, fetuin-A inverted these benign effects of RSFC from an anti- to a proinflammatory status. RSF was quantified by magnetic resonance imaging and liver fat content by (1)H-MR spectroscopy in 449 individuals at risk for type 2 diabetes. Impaired renal function was determined via urinary albumin/creatinine-ratio (uACR). RSF did not correlate with uACR in subjects without NAFLD (n?=?212, p?=?0.94), but correlated positively in subjects with NAFLD (n?=?105, p?=?0.0005). Estimated glomerular filtration rate ?(eGRF) was inversely correlated with RSF, suggesting lower eGFR for subjects with higher RSF (r?=?0.24, p?<?0.0001). In conclusion, our data suggest that in the presence of NAFLD elevated fetuin-A levels may impair renal function by RSF-induced proinflammatory signalling in glomerular cells. Twit Text FOAVip The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28536464 #FOAvip English Wikipedia <ref>{{Cite pmid|28536464 }}</ref> The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A #MMPMID28536464 Wagner R ; Machann J ; Guthoff M ; Nawroth PP ; Nadalin S ; Saleem MA ; Heyne N ; Königsrainer A ; Fend F ; Schick F ; Fritsche A ; Stefan N ; Häring HU ; Schleicher E ; Siegel-Axel DI Sci Rep 2017[May]; 7 (1 ): 2261 PMID28536464 show ga Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC. However, fetuin-A inverted these benign effects of RSFC from an anti- to a proinflammatory status. RSF was quantified by magnetic resonance imaging and liver fat content by (1)H-MR spectroscopy in 449 individuals at risk for type 2 diabetes. Impaired renal function was determined via urinary albumin/creatinine-ratio (uACR). RSF did not correlate with uACR in subjects without NAFLD (n?=?212, p?=?0.94), but correlated positively in subjects with NAFLD (n?=?105, p?=?0.0005). Estimated glomerular filtration rate ?(eGRF) was inversely correlated with RSF, suggesting lower eGFR for subjects with higher RSF (r?=?0.24, p? |Adipocytes/metabolism [MESH] |Adult [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Cytokines/metabolism [MESH] |Female [MESH] |Gene Expression [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Inflammation Mediators/metabolism [MESH] |Intra-Abdominal Fat/diagnostic imaging/*physiology [MESH] |Kidney Glomerulus/*cytology/*metabolism [MESH] |Kidney/*anatomy & histology/diagnostic imaging/*physiology [MESH] |Macrophages/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |RNA, Messenger/genetics [MESH] |Renal Artery/*anatomy & histology/diagnostic imaging [MESH]The protective effect of human renal sinus fat on glomerular cells is (epmc).pdf DeepDyve Pubget Overpricing