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10.1038/s41598-017-02510-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-02510-9 C5442120!5442120 !28536451     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28536451 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 2296 Nephropedia Template TP {{tp|p=28536451 |t=2017. Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes |pdf=|usr=}}{{28536451 }} gab.com Text Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536451 #FOAvip Better understanding the drug action within cells may extend our knowledge on drug action mechanisms and promote new drugs discovery. Herein, we studied the processes of drug induced chemical changes on proteins and nucleic acids in human breast adenocarcinoma (MCF-7) cells via time-resolved plasmonic-enhanced Raman spectroscopy (PERS) in combination with principal component analysis (PCA). Using three popular chemotherapy drugs (fluorouracil, cisplatin and camptothecin) as models, chemical changes during drug action process were clearly discriminated. Reaction kinetics related to protein denaturation, conformational modification, DNA damage and their associated biomolecular events were calculated. Through rate constants and reaction delay times, the different action modes of these drugs could be distinguished. These results may provide vital insights into understanding the chemical reactions associated with drug-cell interactions. Twit Text FOAVip Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28536451 #FOAvip English Wikipedia <ref>{{Cite pmid|28536451 }}</ref> Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes #MMPMID28536451 Li SS ; Guan QY ; Meng G ; Chang XF ; Wei JW ; Wang P ; Kang B ; Xu JJ ; Chen HY Sci Rep 2017[May]; 7 (1 ): 2296 PMID28536451 show ga Better understanding the drug action within cells may extend our knowledge on drug action mechanisms and promote new drugs discovery. Herein, we studied the processes of drug induced chemical changes on proteins and nucleic acids in human breast adenocarcinoma (MCF-7) cells via time-resolved plasmonic-enhanced Raman spectroscopy (PERS) in combination with principal component analysis (PCA). Using three popular chemotherapy drugs (fluorouracil, cisplatin and camptothecin) as models, chemical changes during drug action process were clearly discriminated. Reaction kinetics related to protein denaturation, conformational modification, DNA damage and their associated biomolecular events were calculated. Through rate constants and reaction delay times, the different action modes of these drugs could be distinguished. These results may provide vital insights into understanding the chemical reactions associated with drug-cell interactions. |Adenocarcinoma/genetics/metabolism/pathology [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Breast Neoplasms/genetics/metabolism/pathology [MESH] |Camptothecin/pharmacology [MESH] |Chemical Phenomena [MESH] |Cisplatin/pharmacology [MESH] |Female [MESH] |Fluorouracil/pharmacology [MESH] |Gold/chemistry [MESH] |Humans [MESH] |Kinetics [MESH] |MCF-7 Cells [MESH] |Metal Nanoparticles/chemistry/ultrastructure [MESH] |Principal Component Analysis [MESH] |Protein Denaturation/*drug effects [MESH] |Single-Cell Analysis/*methods [MESH]Revealing chemical processes and kinetics of drug action within single(epmc).pdf DeepDyve Pubget Overpricing