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2017 ; 7
(1
): 2263
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Caffeic Acid Attenuates Diabetic Kidney Disease via Modulation of Autophagy in a
High-Fat Diet/Streptozotocin- Induced Diabetic Rat
#MMPMID28536471
Matboli M
; Eissa S
; Ibrahim D
; Hegazy MGA
; Imam SS
; Habib EK
Sci Rep
2017[May]; 7
(1
): 2263
PMID28536471
show ga
The aim of this study is to evaluate the anti-diabetic nephropathy effect of
Caffeic acid and to prove our hypothesis for its mechanism of action that it may
occur by reactivation of autophagy pathway via suppression of autophagy
regulatory miRNAs. In vivo, high-fat diet and streptozotocin-induced (HFD-STZ)
diabetic rats were treated with Caffeic acid once per day for 12 weeks before and
after development of diabetic nephropathy. Blood and urine biochemical
parameters, autophagy transcripts and their epigenetic regulators together with
renal tissue morphology were investigated. In diabetic rats, Caffeic acid intake,
caused improvement in albumin excretion,blood glucose, reduced renal mesangial
matrix extension with increased vacuolation and reappearance of autophagosomes.
Meanwhile, it resulted in autophagy genes up-regulation [RB 1-inducible coiled
coil protein (RB1CC1), Microtubule-associated proteins 1A/1B light chain
3(MAP1LC3B), Autophagy related gene (ATG-12),] with simultaneous reduction in
their epigenetic regulators; miRNA-133b, -342 and 30a, respectively. These above
mentioned effects were more significant in the diabetic nephropathy Caffeic
treated rats than in the prophylactic group. Based on our results we postulated
that caffeic acid modulates autophagy pathway through inhibition of autophagy
regulatory miRNAs, that could explain its curative properties against diabetic
kidney disease.
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