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10.2217/imt.15.1 http://scihub22266oqcxt.onion/10.2217/imt.15.1 C5441999!5441999!25917630     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25917630&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunotherapy 2015 ; 7 (4): 399-410 Nephropedia Template TP {{tp|p=25917630|t=2015. Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance |pdf=|usr=}}{{25917630}} gab.com Text Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance JO: Immunotherapy http://www.kidney.de/pget.php?&tw=1&pmid=25917630 #FOAvip Since the discovery of the CD40-CD154 costimulatory pathway and its critical role in the adaptive immune response, there has been considerable interest in therapeutically targeting this interaction with monoclonal antibodies in transplantation. Unfortunately, initial promise in animal models gave way to disappointment in clinical trials following a number of thromboembolic complications. However, recent mechanistic studies have identified the mechanism of these adverse events, as well as detailed a myriad of interactions between CD40 and CD154 on a wide variety of immune cell types and the critical role of this pathway in generating both humoral and cell-mediated alloreactive responses. This has led to resurgence in interest and the potential resurrection of anti-CD154 and anti-CD40 antibodies as clinically viable therapeutic options. Twit Text FOAVip Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance ????Immunotherapy http://www.kidney.de/pget.php?&tw=1&pmid=25917630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25917630 #FOAvip English Wikipedia <ref>{{Cite pmid|25917630}}</ref> Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance #MMPMID25917630 Pinelli DF; Ford ML Immunotherapy 2015[]; 7 (4): 399-410 PMID25917630show ga Since the discovery of the CD40-CD154 costimulatory pathway and its critical role in the adaptive immune response, there has been considerable interest in therapeutically targeting this interaction with monoclonal antibodies in transplantation. Unfortunately, initial promise in animal models gave way to disappointment in clinical trials following a number of thromboembolic complications. However, recent mechanistic studies have identified the mechanism of these adverse events, as well as detailed a myriad of interactions between CD40 and CD154 on a wide variety of immune cell types and the critical role of this pathway in generating both humoral and cell-mediated alloreactive responses. This has led to resurgence in interest and the potential resurrection of anti-CD154 and anti-CD40 antibodies as clinically viable therapeutic options. äNovel insights into anti-CD40/CD154 immunotherapy in transplant tolera(epmc).pdf DeepDyve Pubget Overpricing