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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Epidemiol 2017 ; 84 (ä): 95-104 Nephropedia Template TP
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Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES): development of a new tool for systematic reviews #MMPMID28188898
Wieland LS; Berman BM; Altman DG; Barth J; Bouter LM; D?Adamo CR; Linde K; Moher D; Mullins CD; Treweek S; Tunis S; van der Windt DA; Zwarenstein M; Witt C
J Clin Epidemiol 2017[Apr]; 84 (ä): 95-104 PMID28188898show ga
Background: Randomized trials may be designed to provide evidence more strongly related to efficacy or effectiveness of an intervention. When systematic reviews are used to inform clinical or policy decisions, it is important to know the efficacy-effectiveness nature of the included trials. Objective: To develop a tool to characterize randomized trials included in a systematic review on an efficacy-effectiveness continuum. Methods: We extracted rating domains and descriptors from existing tools, and used a modified Delphi procedure to condense the domains and develop a new tool. The feasibility and inter-rater reliability of the tool was tested on trials from 4 systematic reviews. Results: The RITES (Rating of Included Trials on the Efficacy-effectiveness Spectrum) tool rates clinical trials on a 5-point Likert scale in four domains: (1) participant characteristics, (2) trial setting, (3) flexibility of interventions, and (4) clinical relevance of interventions. When RITES was piloted on trials from 3 reviews by unaffiliated raters, ratings were variable (Intraclass Correlation Coefficient 0.25?0.66 for the four domains), but when RITES was used on 1 review by the review authors with expertise on the topic the ratings were consistent (ICCs >0.80. Conclusion: RITES may help to characterize the efficacy-effectiveness nature of trials included in systematic reviews.