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10.1097/TP.0000000000001322

http://scihub22266oqcxt.onion/10.1097/TP.0000000000001322
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suck abstract from ncbi


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pmid27472091
      Transplantation 2017 ; 101 (6 ): 1310-1319
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  • Donor-Transmitted Atherosclerosis Associated With Worsening Cardiac Allograft Vasculopathy After Heart Transplantation: Serial Volumetric Intravascular Ultrasound Analysis #MMPMID27472091
  • Watanabe T ; Seguchi O ; Yanase M ; Fujita T ; Murata Y ; Sato T ; Sunami H ; Nakajima S ; Kataoka Y ; Nishimura K ; Hisamatsu E ; Kuroda K ; Okada N ; Hori Y ; Wada K ; Hata H ; Ishibashi-Ueda H ; Miyamoto Y ; Fukushima N ; Kobayashi J ; Nakatani T
  • Transplantation 2017[Jun]; 101 (6 ): 1310-1319 PMID27472091 show ga
  • BACKGROUND: The influence of preexisting donor-transmitted atherosclerosis (DA) on cardiac allograft vasculopathy (CAV) development remains unclear. METHODS: We performed 3-dimensional intravascular ultrasound (3D-IVUS) analysis in 42 heart transplantation (HTx) recipients at 2.1 ± 0.9 months (baseline) and 12.2 ± 0.4 months post-HTx, as well as consecutive 3D-IVUS analyses up to 3 years post-HTx in 35 of the 42 recipients. Donor-transmitted atherosclerosis was defined as a maximal intimal thickness of 0.5 mm or greater at baseline. Changes in volumetric IVUS parameters were compared in recipients with (DA group) and without DA (DA-free group) at baseline, 1 year, and 3 years post-HTx. RESULTS: Donor-transmitted atherosclerosis was observed in 57.1% of 42 recipients. The DA group exhibited a significantly greater increase in plaque volume at 1 year post-HTx (P < 0.001), leading to increased percent plaque volume (plaque volume/vessel volume, [%]) (P < 0.001) and decreased luminal volume (P = 0.021). Donor-transmitted atherosclerosis was independently associated with a greater increase in percent plaque volume during the first post-HTx year (P = 0.011). From 1 to 3 years post-HTx, the DA group underwent continuous reduction in luminal volume (P = 0.022). These changes resulted in a higher incidence of angiographic CAV at 3 years post-HTx in the DA group (58.8% vs 5.6%, P = 0.002). CONCLUSIONS: This volumetric IVUS study suggests that DA correlates with the worsening change in CAV several years post-HTx. Donor-transmitted atherosclerosis recipients may require more aggressive treatment to prevent subsequent CAV progression.
  • |*Tissue Donors [MESH]
  • |*Ultrasonography, Interventional [MESH]
  • |Adult [MESH]
  • |Allografts [MESH]
  • |Atherosclerosis/*complications/diagnostic imaging [MESH]
  • |Coronary Angiography [MESH]
  • |Coronary Artery Disease/*diagnostic imaging/etiology [MESH]
  • |Disease Progression [MESH]
  • |Female [MESH]
  • |Health Status [MESH]
  • |Heart Transplantation/*adverse effects [MESH]
  • |Humans [MESH]
  • |Imaging, Three-Dimensional [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Plaque, Atherosclerotic [MESH]
  • |Predictive Value of Tests [MESH]
  • |Retrospective Studies [MESH]
  • |Risk Assessment [MESH]
  • |Risk Factors [MESH]
  • |Time Factors [MESH]
  • |Treatment Outcome [MESH]


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