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10.1186/s12974-017-0879-5 http://scihub22266oqcxt.onion/10.1186/s12974-017-0879-5 C5441080!5441080!28532450     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroinflammation 2017 ; 14 (ä): ä Nephropedia Template TP {{tp|p=28532450|t=2017. LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface |pdf=|usr=}}{{28532450}} gab.com Text LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip Background: The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNPTer/Ter) provides a novel model for studying PrPC physiology. Methods: In order to explore putative roles for PrPC in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP+/+ and 8 PRNPTer/Ter) and included 10 saline-treated controls (5 of each PRNP genotype). Clinical examinations were performed continuously, and blood samples were collected throughout the trial. Genome-wide transcription profiles of the choroid plexus, which is at the blood-brain interface, and the hippocampus were analyzed by RNA sequencing, and the same tissues were histologically evaluated. Results: All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p?<?0.01) longer duration in animals without PrPC. In the choroid plexus, a substantial alteration of the transcriptome and activation of Iba1-positive cells were observed. This response included genotype-dependent differential expression of several genes associated with the immune response, such as ISG15, CXCL12, CXCL14, and acute phase proteins, among others. Activation of cytokine-responsive genes was skewed towards a more profound type I interferon response, and a less obvious type II response, in PrPC-deficient goats. The magnitude of gene expression in response to LPS was smaller in the hippocampus than in the choroid plexus. Resting state expression profiles revealed a few differences between the PRNP genotypes. Conclusions: Our data suggest that PrPC acts as a modulator of certain pathways of innate immunity signaling, particularly downstream of interferons, and probably contributes to protection of vulnerable tissues against inflammatory damage. Electronic supplementary material: The online version of this article (doi:10.1186/s12974-017-0879-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip English Wikipedia <ref>{{Cite pmid|28532450}}</ref> LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface #MMPMID28532450 Salvesen Ø; Reiten MR; Espenes A; Bakkebø MK; Tranulis MA; Ersdal C J Neuroinflammation 2017[]; 14 (ä): ä PMID28532450show ga Background: The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNPTer/Ter) provides a novel model for studying PrPC physiology. Methods: In order to explore putative roles for PrPC in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP+/+ and 8 PRNPTer/Ter) and included 10 saline-treated controls (5 of each PRNP genotype). Clinical examinations were performed continuously, and blood samples were collected throughout the trial. Genome-wide transcription profiles of the choroid plexus, which is at the blood-brain interface, and the hippocampus were analyzed by RNA sequencing, and the same tissues were histologically evaluated. Results: All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p? äLPS-induced systemic inflammation reveals an immunomodulatory role for(epmc).pdf DeepDyve Pubget Overpricing