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10.1186/s12974-017-0879-5 http://scihub22266oqcxt.onion/10.1186/s12974-017-0879-5 C5441080!5441080 !28532450     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28532450 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neuroinflammation 2017 ; 14 (1 ): 106 Nephropedia Template TP {{tp|p=28532450 |t=2017. LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface |pdf=|usr=}}{{28532450 }} gab.com Text LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip BACKGROUND: The cellular prion protein (PrP(C)) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrP(C) (PRNP (Ter/Ter)) provides a novel model for studying PrP(C) physiology. METHODS: In order to explore putative roles for PrP(C) in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP (+/+) and 8 PRNP (Ter/Ter)) and included 10 saline-treated controls (5 of each PRNP genotype). Clinical examinations were performed continuously, and blood samples were collected throughout the trial. Genome-wide transcription profiles of the choroid plexus, which is at the blood-brain interface, and the hippocampus were analyzed by RNA sequencing, and the same tissues were histologically evaluated. RESULTS: All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p?<?0.01) longer duration in animals without PrP(C). In the choroid plexus, a substantial alteration of the transcriptome and activation of Iba1-positive cells were observed. This response included genotype-dependent differential expression of several genes associated with the immune response, such as ISG15, CXCL12, CXCL14, and acute phase proteins, among others. Activation of cytokine-responsive genes was skewed towards a more profound type I interferon response, and a less obvious type II response, in PrP(C)-deficient goats. The magnitude of gene expression in response to LPS was smaller in the hippocampus than in the choroid plexus. Resting state expression profiles revealed a few differences between the PRNP genotypes. CONCLUSIONS: Our data suggest that PrP(C) acts as a modulator of certain pathways of innate immunity signaling, particularly downstream of interferons, and probably contributes to protection of vulnerable tissues against inflammatory damage. Twit Text FOAVip LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28532450 #FOAvip English Wikipedia <ref>{{Cite pmid|28532450 }}</ref> LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface #MMPMID28532450 Salvesen Ø ; Reiten MR ; Espenes A ; Bakkebø MK ; Tranulis MA ; Ersdal C J Neuroinflammation 2017[May]; 14 (1 ): 106 PMID28532450 show ga BACKGROUND: The cellular prion protein (PrP(C)) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrP(C) (PRNP (Ter/Ter)) provides a novel model for studying PrP(C) physiology. METHODS: In order to explore putative roles for PrP(C) in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP (+/+) and 8 PRNP (Ter/Ter)) and included 10 saline-treated controls (5 of each PRNP genotype). Clinical examinations were performed continuously, and blood samples were collected throughout the trial. Genome-wide transcription profiles of the choroid plexus, which is at the blood-brain interface, and the hippocampus were analyzed by RNA sequencing, and the same tissues were histologically evaluated. RESULTS: All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p? |Animals [MESH] |Animals, Genetically Modified [MESH] |Brain/*metabolism [MESH] |Calcium-Binding Proteins [MESH] |Choroid Plexus/metabolism/pathology [MESH] |Chromatin Immunoprecipitation [MESH] |Cytokines/metabolism [MESH] |DNA-Binding Proteins/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation/drug effects/genetics [MESH] |Gene Ontology [MESH] |Genotype [MESH] |Goats [MESH] |Illness Behavior/drug effects/physiology [MESH] |Immunity, Innate/drug effects [MESH] |Inflammation/*blood/chemically induced/*immunology/*pathology [MESH] |Lipopolysaccharides/toxicity [MESH] |Microfilament Proteins [MESH] |Prion Proteins/blood/genetics/*metabolism [MESH] |RNA, Messenger/metabolism [MESH]LPS-induced systemic inflammation reveals an immunomodulatory role for(epmc).pdf DeepDyve Pubget Overpricing