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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Transl+Med 2017 ; 15 (ä): ä Nephropedia Template TP
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The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications #MMPMID28532423
Ren N; Atyah M; Chen WY; Zhou CH
J Transl Med 2017[]; 15 (ä): ä PMID28532423show ga
Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents? genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells.