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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Cell+Infect+Microbiol
2017 ; 7
(ä): 208
Nephropedia Template TP
gab.com Text
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Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to
Hijack the Eukaryotic Cell Cycle and Promote Infections
#MMPMID28589102
El-Aouar Filho RA
; Nicolas A
; De Paula Castro TL
; Deplanche M
; De Carvalho Azevedo VA
; Goossens PL
; Taieb F
; Lina G
; Le Loir Y
; Berkova N
Front Cell Infect Microbiol
2017[]; 7
(ä): 208
PMID28589102
show ga
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order
to subvert the host response for their own benefit, leading to successful
colonization and invasion. Pathogenic bacteria produce multiple compounds that
generate favorable conditions to their survival and growth during infection in
eukaryotic hosts. Many bacterial toxins can alter the cell cycle progression of
host cells, impairing essential cellular functions and impeding host cell
division. This review summarizes current knowledge regarding cyclomodulins, a
heterogeneous family of bacterial effectors that induce eukaryotic cell cycle
alterations. We discuss the mechanisms of actions of cyclomodulins according to
their biochemical properties, providing examples of various cyclomodulins such as
cycle inhibiting factor, ?-glutamyltranspeptidase, cytolethal distending toxins,
shiga toxin, subtilase toxin, anthrax toxin, cholera toxin, adenylate cyclase
toxins, vacuolating cytotoxin, cytotoxic necrotizing factor, Panton-Valentine
leukocidin, phenol soluble modulins, and mycolactone. Special attention is paid
to the benefit provided by cyclomodulins to bacteria during colonization of the
host.