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2017 ; 7
(ä): 191
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Diversity and Versatility of Phagocytosis: Roles in Innate Immunity, Tissue
Remodeling, and Homeostasis
#MMPMID28589095
Lim JJ
; Grinstein S
; Roth Z
Front Cell Infect Microbiol
2017[]; 7
(ä): 191
PMID28589095
show ga
Phagocytosis, a critical early event in the microbicidal response of neutrophils,
is now appreciated to serve multiple functions in a variety of cell types.
Professional phagocytes play a central role in innate immunity by eliminating
pathogenic bacteria, fungi and malignant cells, and contribute to adaptive
immunity by presenting antigens to lymphocytes. In addition, phagocytes play a
part in tissue remodeling and maintain overall homeostasis by disposing of
apoptotic cells, a task shared by non-professional phagocytes, often of
epithelial origin. This functional versatility is supported by a vast array of
receptors capable of recognizing a striking variety of foreign and endogenous
ligands. Here we present an abbreviated overview of the different types of
phagocytes, their varied modes of signaling and particle engulfment, and the
multiple physiological roles of phagocytosis.