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2017 ; 11
(2
): 191-192
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Beyond immunomodulation: The regenerative role for regulatory T cells in central
nervous system remyelination
#MMPMID28493107
Miron VE
J Cell Commun Signal
2017[Jun]; 11
(2
): 191-192
PMID28493107
show ga
Central nervous system regeneration after injury can occur in the form of
remyelination, the reinstatement of myelin around axons which restores axon
health and function. However, remyelination often fails in chronic neurological
diseases, such as progressive multiple sclerosis. The lack of currently approved
pro-remyelination therapies highlights the need to elucidate the cellular and
molecular mechanisms underpinning this regenerative process. Whereas some T
lymphocyte subsets such as Th1 and Th17 are implicated in inducing myelin injury,
a recent study by Dombrowski et al. reveals a novel role for regulatory T cells
(T(regs)) in directly driving remyelination, independent of immunomodulation (Nat
Neurosci doi: 10.1038/nn.4528 2017)(Dombrowski et al., 2017). This study is
summarized in this Bits and Bytes.