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2017 ; 11
(5
): e0005601
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Functional and phenotypic evaluation of eosinophils from patients with the acute
form of paracoccidioidomycosis
#MMPMID28489854
Braga FG
; Ruas LP
; Pereira RM
; Lima XT
; Antunes E
; Mamoni RL
; Blotta MHSL
PLoS Negl Trop Dis
2017[May]; 11
(5
): e0005601
PMID28489854
show ga
BACKGROUND: Eosinophilia is a typical finding of the acute/juvenile form of
paracoccidioidomycosis (PCM), a systemic mycosis endemic in Latin America. This
clinical form is characterized by depressed cellular immune response and
production of Th2 cytokines. Moreover, it has been shown that the increased
number of eosinophils in peripheral blood of patients returns to normal values
after antifungal treatment. However, the role of eosinophils in PCM has never
been evaluated. This study aimed to assess the phenotypic and functional
characteristics of eosinophils in PCM. METHODS/PRINCIPAL FINDINGS: In 15 patients
with the acute form of the disease, we detected expression of MBP, CCL5 (RANTES)
and CCL11 (eotaxin) in biopsies of lymph nodes and liver. In addition, there were
higher levels of chemokines and granule proteins in the peripheral blood of
patients compared to controls. Isolation of eosinophils from blood revealed a
higher frequency of CD69+ and TLR2+ eosinophils in patients compared to controls,
and a lower population of CD80+ cells. We also evaluated the fungicidal capacity
of eosinophils in vitro. Our results revealed that eosinophils from PCM patients
and controls exhibit similar ability to kill P. brasiliensis yeast cells,
although eosinophils of patients were less responsive to IL-5 stimulation than
controls. CONCLUSION/PRINCIPAL FINDINGS: In conclusion, we suggest that
eosinophils might play a role in the host response to fungi and in the
pathophysiology of PCM by inducing an intense and systemic inflammatory response
in the initial phase of the infection.
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