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10.1016/j.semnephrol.2016.01.003

http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2016.01.003
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C5439503!5439503!27085736
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suck abstract from ncbi

pmid27085736      Semin+Nephrol 2016 ; 36 (1): 62-70
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  • Targeting Iron Homeostasis in Acute Kidney Injury #MMPMID27085736
  • Walker VJ; Agarwal A
  • Semin Nephrol 2016[Jan]; 36 (1): 62-70 PMID27085736show ga
  • Iron is an essential metal involved in several major cellular processes required to maintain life. Because of iron?s ability to cause oxidative damage, its transport, metabolism, and storage is strictly controlled in the body, especially in the small intestine, liver, and kidney. Iron plays a major role in acute kidney injury and has been a target for therapeutic intervention. However, the therapies that have been effective in animal models of acute kidney injury have not been successful in human beings. Targeting iron trafficking via ferritin, ferroportin, or hepcidin may offer new insights. This review focuses on the biology of iron, particularly in the kidney, and its implications in acute kidney injury.
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