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10.1002/dmrr.1250 http://scihub22266oqcxt.onion/10.1002/dmrr.1250 C5439426!5439426!22069258     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+Res+Rev 2011 ; 27 (8): 773-7 Nephropedia Template TP {{tp|p=22069258|t=2011. Insulin as a key autoantigen in the development of type 1 diabetes |pdf=|usr=}}{{22069258}} gab.com Text Insulin as a key autoantigen in the development of type 1 diabetes JO: Diabetes Metab Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=22069258 #FOAvip Type 1 diabetes is a T-cell-mediated autoimmune disease against pancreatic beta cells. T cells target various antigens such as insulin, chromogranin A, glutamic acid decarboxylase and islet-specific glucose-6-phosphatase catalytic subunit-related protein. Elimination of insulin dramatically prevents diabetes in the non-obese diabetic (NOD) mouse model and response to insulin occurs prior to that to other antigens. These findings suggest that insulin is a target antigen at the early stage of the disease and is likely to be essential to cause anti-islet autoimmunity in NOD mice. In this review, we discuss whether insulin is truly essential and is only the single essential autoantigen for NOD mice and potentially for man. Although the ultimate principle is still being addressed, it is certain that T-cell response to insulin is a major check point to develop type 1 diabetes in NOD mice. Given multiple similarities between diabetes of NOD mice and man, targeting insulin and insulin-reactive T cells may provide opportunities to develop robust immunotherapies. Twit Text FOAVip Insulin as a key autoantigen in the development of type 1 diabetes ????Diabetes Metab Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=22069258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22069258 #FOAvip English Wikipedia <ref>{{Cite pmid|22069258}}</ref> Insulin as a key autoantigen in the development of type 1 diabetes #MMPMID22069258 Nakayama M Diabetes Metab Res Rev 2011[Nov]; 27 (8): 773-7 PMID22069258show ga Type 1 diabetes is a T-cell-mediated autoimmune disease against pancreatic beta cells. T cells target various antigens such as insulin, chromogranin A, glutamic acid decarboxylase and islet-specific glucose-6-phosphatase catalytic subunit-related protein. Elimination of insulin dramatically prevents diabetes in the non-obese diabetic (NOD) mouse model and response to insulin occurs prior to that to other antigens. These findings suggest that insulin is a target antigen at the early stage of the disease and is likely to be essential to cause anti-islet autoimmunity in NOD mice. In this review, we discuss whether insulin is truly essential and is only the single essential autoantigen for NOD mice and potentially for man. Although the ultimate principle is still being addressed, it is certain that T-cell response to insulin is a major check point to develop type 1 diabetes in NOD mice. Given multiple similarities between diabetes of NOD mice and man, targeting insulin and insulin-reactive T cells may provide opportunities to develop robust immunotherapies. äInsulin as a key autoantigen in the development of type 1 diabetes (epmc).pdf DeepDyve Pubget Overpricing