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10.1093/jmcb/mjx004 http://scihub22266oqcxt.onion/10.1093/jmcb/mjx004 C5439424!5439424!28093454     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2017 ; 9 (1): 16-25 Nephropedia Template TP {{tp|p=28093454|t=2017. Mdm proteins: critical regulators of embryogenesis and homoeostasis |pdf=|usr=}}{{28093454}} gab.com Text Mdm proteins: critical regulators of embryogenesis and homoeostasis JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28093454 #FOAvip Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancer-related studies. A multitude of experiments across various developmental stages have been conducted to explore the tissue-specific roles of these proteins in the mouse. When Mdm2 or Mdm4 are deleted in the germline or specific tissues, they display different phenotypic defects, some of which lead to embryonic lethality. Mdm2 loss is often more deleterious than loss of its homologue Mdm4. All tissues experience activation of p53 target genes upon loss of Mdm2 or Mdm4; however, the degree to which the p53 pathway is perturbed is highly tissue-specific and does not correlate to the severity of the morphological phenotypes. Therefore, a need for further understanding of how these proteins regulate p53 activity is warranted, as therapeutic targeting of the p53 pathway is rapidly evolving and gaining attention in the field of cancer research. In this review, we discuss the tissue-specificity of Mdm proteins in regulating p53 and expose the need for investigation at the cell-specific level. Twit Text FOAVip Mdm proteins: critical regulators of embryogenesis and homoeostasis ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28093454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28093454 #FOAvip English Wikipedia <ref>{{Cite pmid|28093454}}</ref> Mdm proteins: critical regulators of embryogenesis and homoeostasis #MMPMID28093454 Moyer SM; Larsson CA; Lozano G J Mol Cell Biol 2017[Feb]; 9 (1): 16-25 PMID28093454show ga Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancer-related studies. A multitude of experiments across various developmental stages have been conducted to explore the tissue-specific roles of these proteins in the mouse. When Mdm2 or Mdm4 are deleted in the germline or specific tissues, they display different phenotypic defects, some of which lead to embryonic lethality. Mdm2 loss is often more deleterious than loss of its homologue Mdm4. All tissues experience activation of p53 target genes upon loss of Mdm2 or Mdm4; however, the degree to which the p53 pathway is perturbed is highly tissue-specific and does not correlate to the severity of the morphological phenotypes. Therefore, a need for further understanding of how these proteins regulate p53 activity is warranted, as therapeutic targeting of the p53 pathway is rapidly evolving and gaining attention in the field of cancer research. In this review, we discuss the tissue-specificity of Mdm proteins in regulating p53 and expose the need for investigation at the cell-specific level. äMdm proteins: critical regulators of embryogenesis and homoeostasis (epmc).pdf DeepDyve Pubget Overpricing