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10.1093/jmcb/mjw052 http://scihub22266oqcxt.onion/10.1093/jmcb/mjw052 C5439402!5439402!27932484     free     free     free       J+Mol+Cell+Biol 2017 ; 9 (1): 69-73 Nephropedia Template TP {{tp|p=27932484|t=2017. Role of Mdm2 and Mdmx in DNA repair |pdf=|usr=}}{{27932484}} gab.com Text Role of Mdm2 and Mdmx in DNA repair JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27932484 #FOAvip Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53. Twit Text FOAVip Role of Mdm2 and Mdmx in DNA repair ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27932484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27932484 #FOAvip English Wikipedia <ref>{{Cite pmid|27932484}}</ref> Role of Mdm2 and Mdmx in DNA repair #MMPMID27932484 Eischen CM J Mol Cell Biol 2017[Feb]; 9 (1): 69-73 PMID27932484show ga Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53. äRole of Mdm2 and Mdmx in DNA repair (epmc).pdf DeepDyve Pubget Overpricing