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2017 ; 4
(ä): 61
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English Wikipedia
The Future of Bronchopulmonary Dysplasia: Emerging Pathophysiological Concepts
and Potential New Avenues of Treatment
#MMPMID28589122
Collins JJP
; Tibboel D
; de Kleer IM
; Reiss IKM
; Rottier RJ
Front Med (Lausanne)
2017[]; 4
(ä): 61
PMID28589122
show ga
Yearly more than 15 million babies are born premature (<37?weeks gestational
age), accounting for more than 1 in 10 births worldwide. Lung injury caused by
maternal chorioamnionitis or preeclampsia, postnatal ventilation, hyperoxia, or
inflammation can lead to the development of bronchopulmonary dysplasia (BPD), one
of the most common adverse outcomes in these preterm neonates. BPD patients have
an arrest in alveolar and microvascular development and more frequently develop
asthma and early-onset emphysema as they age. Understanding how the alveoli
develop, and repair, and regenerate after injury is critical for the development
of therapies, as unfortunately there is still no cure for BPD. In this review, we
aim to provide an overview of emerging new concepts in the understanding of
perinatal lung development and injury from a molecular and cellular point of view
and how this is paving the way for new therapeutic options to prevent or treat
BPD, as well as a reflection on current treatment procedures.