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10.3389/fcimb.2017.00195 http://scihub22266oqcxt.onion/10.3389/fcimb.2017.00195 C5438986!5438986 !28589097     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28589097 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Cell+Infect+Microbiol 2017 ; 7 (ä): 195 Nephropedia Template TP {{tp|p=28589097 |t=2017. AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300 |pdf=|usr=}}{{28589097 }} gab.com Text AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300 JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28589097 #FOAvip Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN) production, which depends on coordinated activity of multiple transcription factors. IFN regulatory factor 3 (IRF3) and transcriptional coactivator CREB binding protein (CBP) and/or p300 are core factors that participate in transcriptional complex formation in the nucleus. In general, cells balance the production of IFNs through suppressive and stimulative mechanisms, but viral infections can disrupt such equilibrium. This study determined that H5N1 viral infection reduced the distribution of human argonaute 2 (AGO2) in A549 cell nucleus. AGO2 did not block phosphorylation, nuclear translocation, and DNA binding ability of IRF3 but inhibited its association with CBP. Therefore, this newly revealed mechanism shows that cellular response leads to transfer of AGO2 from cell nucleus and promotes IFN-? expression to increase host survival during viral infection. Twit Text FOAVip AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300 ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28589097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28589097 #FOAvip English Wikipedia <ref>{{Cite pmid|28589097 }}</ref> AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300 #MMPMID28589097 Wang S ; Sun X ; Yi C ; Zhang D ; Lin X ; Sun X ; Chen H ; Jin M Front Cell Infect Microbiol 2017[]; 7 (ä): 195 PMID28589097 show ga Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN) production, which depends on coordinated activity of multiple transcription factors. IFN regulatory factor 3 (IRF3) and transcriptional coactivator CREB binding protein (CBP) and/or p300 are core factors that participate in transcriptional complex formation in the nucleus. In general, cells balance the production of IFNs through suppressive and stimulative mechanisms, but viral infections can disrupt such equilibrium. This study determined that H5N1 viral infection reduced the distribution of human argonaute 2 (AGO2) in A549 cell nucleus. AGO2 did not block phosphorylation, nuclear translocation, and DNA binding ability of IRF3 but inhibited its association with CBP. Therefore, this newly revealed mechanism shows that cellular response leads to transfer of AGO2 from cell nucleus and promotes IFN-? expression to increase host survival during viral infection. |*Signal Transduction [MESH] |A549 Cells [MESH] |Animals [MESH] |Argonaute Proteins/*metabolism [MESH] |CREB-Binding Protein/*metabolism [MESH] |Cell Nucleus/metabolism [MESH] |Cell Proliferation [MESH] |Dogs [MESH] |E1A-Associated p300 Protein/*metabolism [MESH] |HEK293 Cells [MESH] |Host-Pathogen Interactions/immunology [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Influenza A Virus, H5N1 Subtype/immunology [MESH] |Influenza, Human/immunology [MESH] |Interferon Regulatory Factor-3/*metabolism [MESH] |Interferon Type I/*metabolism [MESH] |Interferon-beta/metabolism [MESH] |Madin Darby Canine Kidney Cells [MESH] |Phosphorylation [MESH] |Translocation, Genetic [MESH]AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Compe(epmc).pdf DeepDyve Pubget Overpricing