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10.5021/ad.2017.29.3.283

http://scihub22266oqcxt.onion/10.5021/ad.2017.29.3.283
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C5438933!5438933!28566903
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suck abstract from ncbi


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pmid28566903      Ann+Dermatol 2017 ; 29 (3): 283-7
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  • Risk Factors for Aseptic Meningitis in Herpes Zoster Patients #MMPMID28566903
  • Kim SH; Choi SM; Kim BC; Choi KH; Nam TS; Kim JT; Lee SH; Park MS; Kim SJ
  • Ann Dermatol 2017[Jun]; 29 (3): 283-7 PMID28566903show ga
  • Background: Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period. Objective: A retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development. Methods: We included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis. Results: The demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (p=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, p=0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (p=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (p=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (p=0.006). Conclusion: In HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.
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