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10.1007/s13730-016-0240-3

http://scihub22266oqcxt.onion/10.1007/s13730-016-0240-3
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C5438805!5438805!28509125
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suck abstract from ncbi


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pmid28509125      CEN+Case+Rep 2017 ; 6 (1): 39-45
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  • A case of PR3?ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy #MMPMID28509125
  • Manabe S; Banno M; Nakano M; Fujii T; Kakuta Y; Nitta K; Hatano M
  • CEN Case Rep 2017[May]; 6 (1): 39-45 PMID28509125show ga
  • Coexistence of anti-glomerular basement membrane (anti-GBM) disease with anti-neutrophil cytoplasmic antibody (ANCA) is occasionally reported and termed ?double positive? disease. Interestingly, the majority of ?double positive? ANCA is myeloperoxidase (MPO)?ANCA, and some of the MPO?ANCA-positive cases reveal intrarenal arteritis indicating an ANCA-associated renal lesion. In contrast, proteinase 3 (PR3)?ANCA-positive ?double positive? disease had rarely been reported, and as far as we know, none of the cases showed intrarenal arteritis. Herein, we report a case of PR3?ANCA-positive ?double positive? anti-GBM disease presenting with pulmonary-renal syndrome and hemolytic uremic syndrome. The kidney biopsy showed crescentic glomerulonephritis, intrarenal arteritis, and thrombotic microangiopathy. This case newly describes PR3?ANCA-associated intrarenal arteritis in ?double positive? anti-GBM disease.
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