Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00125-014-3459-6 http://scihub22266oqcxt.onion/10.1007/s00125-014-3459-6 C5438751!5438751!25476525     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetologia 2015 ; 58 (3): 543-8 Nephropedia Template TP {{tp|p=25476525|t=2015. SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage Genome Wide Association Study in type 1 diabetes patients |pdf=|usr=}}{{25476525}} gab.com Text SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage Genome Wide Association Study in type 1 diabetes patients JO: Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=25476525 #FOAvip Background: The genetic determinants of diabetic nephropathy remain poorly understood. We aimed to identify novel susceptibility genes for diabetic nephropathy. Patients and methods: We performed a genome-wide association study using 1000 Genomes-based imputation in type 1 diabetic patients comparing diabetic nephropathy cases with proteinuria with or without renal failure to controls with diabetes for more than 15 years and no evidence of renal disease. Results: None of the SNPs tested in a discovery cohort composed of 683 cases and 779 controls reached genome-wide statistical significance. The 46 top hits (p-value < 10?5) were then sought for first-stage analysis in US-GoKinD an independent population of 820 cases and 885 controls. Two SNPs, in strong linkage disequilibrium with each other, located in the SORBS1 gene, were consistently and significantly (p < 10?4) associated with diabetic nephropathy. The minor rs1326934-C allele was less frequent in cases than in controls (0.34 vs 0.43) and was associated with a decreased risk for diabetic nephropathy: OR = 0.70 [0.60 ? 0.82]. However, this association was not observed in a second-stage with two additional diabetic nephropathy cohorts UK-ROI (p=0.15) and FINNDIANE (p = 0.44) totaling 2,142 cases and 2,494 controls. Altogether, the random-effect meta-analyzed rs1326934-C allele OR for diabetic nephropathy was 0.83 [0.72 ? 0.96] (p = 0.009). Conclusion: These data suggest that SORBS1 might be a gene involved in diabetic nephropathy. Twit Text FOAVip SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage Genome Wide Association Study in type 1 diabetes patients ????Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=25476525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25476525 #FOAvip English Wikipedia <ref>{{Cite pmid|25476525}}</ref> SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage Genome Wide Association Study in type 1 diabetes patients #MMPMID25476525 GERMAIN M; PEZZOLESI MG; SANDHOLM N; McKNIGHT AJ; SUSZTAK K; LAJER M; FORSBLOM C; MARRE M; PRARVING HH; ROSSING P; TOPPILA I; SKUPIEN J; ROUSSEL R; KO YA; LEDO N; FOLKERSEN L; CIVELEK M; MAXWELL AP; TREGOUET DA; GROOP PH; TARNOW L; HADJADJ S Diabetologia 2015[Mar]; 58 (3): 543-8 PMID25476525show ga Background: The genetic determinants of diabetic nephropathy remain poorly understood. We aimed to identify novel susceptibility genes for diabetic nephropathy. Patients and methods: We performed a genome-wide association study using 1000 Genomes-based imputation in type 1 diabetic patients comparing diabetic nephropathy cases with proteinuria with or without renal failure to controls with diabetes for more than 15 years and no evidence of renal disease. Results: None of the SNPs tested in a discovery cohort composed of 683 cases and 779 controls reached genome-wide statistical significance. The 46 top hits (p-value < 10?5) were then sought for first-stage analysis in US-GoKinD an independent population of 820 cases and 885 controls. Two SNPs, in strong linkage disequilibrium with each other, located in the SORBS1 gene, were consistently and significantly (p < 10?4) associated with diabetic nephropathy. The minor rs1326934-C allele was less frequent in cases than in controls (0.34 vs 0.43) and was associated with a decreased risk for diabetic nephropathy: OR = 0.70 [0.60 ? 0.82]. However, this association was not observed in a second-stage with two additional diabetic nephropathy cohorts UK-ROI (p=0.15) and FINNDIANE (p = 0.44) totaling 2,142 cases and 2,494 controls. Altogether, the random-effect meta-analyzed rs1326934-C allele OR for diabetic nephropathy was 0.83 [0.72 ? 0.96] (p = 0.009). Conclusion: These data suggest that SORBS1 might be a gene involved in diabetic nephropathy. äSORBS1 gene, a new candidate for diabetic nephropathy: results from a (epmc).pdf DeepDyve Pubget Overpricing