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2017 ; 8
(17
): 29501-29518
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Update of IGF-1 receptor inhibitor (ganitumab, dalotuzumab, cixutumumab,
teprotumumab and figitumumab) effects on cancer therapy
#MMPMID28427155
Qu X
; Wu Z
; Dong W
; Zhang T
; Wang L
; Pang Z
; Ma W
; Du J
Oncotarget
2017[Apr]; 8
(17
): 29501-29518
PMID28427155
show ga
BACKGROUND: Prognostic studies of insulin-like growth factor-1 receptor(IGF-1R)
inhibitors in cancer therapy had promising results in infratests, which exhibited
that IGF-1R signalling was crucial in cancer cells growth. However, the
conclusion of later clinical trials revealed a dim future for IGF-1R inhibitors
to treat cancer. We conducted this analysis to figure out how IGF-1R inhibitors
acted in clinical cancer therapy. MATERIAL AND METHODS: We searched up-to-date
studies about the single agent of IGF-1R inhibitors or combination with other
therapies in solid tumor. Five IGF-1R anti-agents were involved. The primary
endpoint was progression-free survival (PFS). The secondary endpoint was overall
survival (OS). RESULT: 17studies were enrolled. The results was not significant
in overall survival (I2=37.1%, P=0.080, HR=1.08, 95% CI=0.97-1.21) and in
progression-free survival (I2=0.0%, P=0.637, HR=1.05, 95% CI=0.98-1.12). OS for
dalotuzumab, breast cancer, colorectal cancer, and PFS for prostate cancer even
indicated harmful effects. CONCLUSION: So far, anti-IGF-1R mono-antibodies did
not make significant differences in solid tumor prognosis. On the contrary,
pessimistic effects were shown in the dalotuzumab, breast cancer, colorectal
cancer and prostate cancer subgroups. Further studies of IGF-1R anti-agents were
needed, but unwarranted in unselected patients by predictive biomarkers.
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