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10.18632/oncotarget.15298

http://scihub22266oqcxt.onion/10.18632/oncotarget.15298
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C5438745!5438745!28206978
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suck abstract from ncbi


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pmid28206978      Oncotarget 2017 ; 8 (17): 29474-86
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  • Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis #MMPMID28206978
  • Du C; Yang S; Zhao X; Dong H
  • Oncotarget 2017[Apr]; 8 (17): 29474-86 PMID28206978show ga
  • Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric cancer. Here, we reviewed the current studies on vitamin D and its receptor and focused on the pathogenic roles of their alterations in gastric tumorigenesis.
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