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10.18632/oncotarget.16248 http://scihub22266oqcxt.onion/10.18632/oncotarget.16248 C5438716!5438716!28418858     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (17): 29101-15 Nephropedia Template TP {{tp|p=28418858|t=2017. The miR-124-p63 feedback loop modulates colorectal cancer growth |pdf=|usr=}}{{28418858}} gab.com Text The miR-124-p63 feedback loop modulates colorectal cancer growth JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28418858 #FOAvip Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ?Np63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. Taken together, these results reveal a feedback loop between miRNAs and TFs. This feedback loop comprises miR-124, iASPP, STAT1, miR-155, TAp63 and ?Np63, which are essential for CRC growth. Moreover, this feedback loop is perturbed in human colon carcinomas, which suggests that the manipulation of this microRNA-TF feedback loop has therapeutic potential for CRC. Twit Text FOAVip The miR-124-p63 feedback loop modulates colorectal cancer growth ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28418858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28418858 #FOAvip English Wikipedia <ref>{{Cite pmid|28418858}}</ref> The miR-124-p63 feedback loop modulates colorectal cancer growth #MMPMID28418858 Liu K; Yao H; Lei S; Xiong L; Qi H; Qian K; Liu J; Wang P; Zhao H Oncotarget 2017[Apr]; 8 (17): 29101-15 PMID28418858show ga Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ?Np63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. Taken together, these results reveal a feedback loop between miRNAs and TFs. This feedback loop comprises miR-124, iASPP, STAT1, miR-155, TAp63 and ?Np63, which are essential for CRC growth. Moreover, this feedback loop is perturbed in human colon carcinomas, which suggests that the manipulation of this microRNA-TF feedback loop has therapeutic potential for CRC. äThe miR-124-p63 feedback loop modulates colorectal cancer growth (epmc).pdf DeepDyve Pubget Overpricing