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2017 ; 8
(17
): 29091-29100
Nephropedia Template TP
gab.com Text
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English Wikipedia
Pseudogene PHBP1 promotes esophageal squamous cell carcinoma proliferation by
increasing its cognate gene PHB expression
#MMPMID28404970
Feng F
; Qiu B
; Zang R
; Song P
; Gao S
Oncotarget
2017[Apr]; 8
(17
): 29091-29100
PMID28404970
show ga
Natural antisense transcripts (NATs) as one of the most diverse classes of long
noncoding RNAs (lncRNAs), have been demonstrated involved in fundamental
biological processes in human. Here, we reported that human prohibitin gene
pseudogene 1 (PHBP1) was upregulated in ESCC, and increased PHBP1 expression in
ESCC was associated with clinical advanced stage. Functional experiments showed
that PHBP1 knockdown inhibited ESCC cells proliferation, colony formation and
xenograft tumor growth in vitro and in vivo by causing cell-cycle arrest at the
G1-G0 phase. Mechanisms analysis revealed that PHBP1 transcript as an antisense
transcript of PHB is partially complementary to PHB mRNA and formed an RNA-RNA
hybrid with PHB, consequently inducing an increase of PHB expression at both the
mRNA and protein levels. Furthermore, PHBP1 expression is strongly correlated
with PHB expression in ESCC tissues. Collectively, this study elucidates an
important role of PHBP1 in promoting ESCC partly via increasing PHB expression.