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10.18632/oncotarget.15640

http://scihub22266oqcxt.onion/10.18632/oncotarget.15640
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C5438683!5438683!28404923
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suck abstract from ncbi


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pmid28404923      Oncotarget 2017 ; 8 (17): 28683-95
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  • Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis #MMPMID28404923
  • Li C; Miao R; Liu S; Wan Y; Zhang S; Deng Y; Bi J; Qu K; Zhang J; Liu C
  • Oncotarget 2017[Apr]; 8 (17): 28683-95 PMID28404923show ga
  • MicroRNAs play an important role in liver cancer genesis and progression. In this study, we identified down-regulation of miR-146b-5p associated with tumor growth, metastasis and poor survival in hepatocellular carcinoma (HCC) patients. miR-146b-5p could suppress proliferation, migration, and invasion and induced apoptosis in vitro and in vivo. Remarkably, TNF receptor associated factor 6 (TRAF6) was confirmed as a direct target of miR-146b-5p in HCC and miR-146b-5p exerted the tumor suppression roles through inhibiting the phosphorylation of Akt mediated by TRAF6. Furthermore, we identified long non-coding RNA MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC. In general, our results indicate that miR-146b-5p inhibits tumor growth and metastasis of HCC by targeting TRAF6 mediated Akt phosphorylation.
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