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10.18632/oncotarget.15639 http://scihub22266oqcxt.onion/10.18632/oncotarget.15639 C5438682!5438682!28404922     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (17): 28672-82 Nephropedia Template TP {{tp|p=28404922|t=2017. Adipophilin as prognostic biomarker in clear cell renal cell carcinoma |pdf=|usr=}}{{28404922}} gab.com Text Adipophilin as prognostic biomarker in clear cell renal cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28404922 #FOAvip Objective: To study the expression of adipophilin (PLIN2), a lipid storage-associated cell protein, in different subtypes of renal cell cancer and to elucidate its prognostic value. Materials and Methods: Two-hundred-seventy-five patients with renal cell carcinoma (RCC) were included in this study. Immunohistochemistry with a polyclonal antibody to adipophilin was used on the tissue microarray (formalin-fixed, paraffin-embedded tissue) for detection of adipophilin. Median follow-up time was 91 (range 1-159) months in the whole cohort and 100 (1-159) months for patients with clear-cell RCC. Additional validation for adipophilin was performed using publicly available gene expression data for clear cell RCC from The Cancer Genome Atlas (TCGA). Results: Adipophilin expression was detected in 14.3% of papillary RCC, in 0% of chromophobe RCC and in 58.7% of clear-cell RCC in the cytoplasm or at the membrane. Only membrane expression was correlated with other clinical parameters (pT-stage, pN-stage, R-status, sex) and showed a prognostic significance in univariate analysis with regard to overall survival of patients with clear cell subtype (HR 2.90, 95% CI 1.55-5.42, p=0.001), which failed significance on multivariate analysis. mRNA expression of PLIN2 on TCGA data using best selected cut-off was prognostically significant in both univariate (HR 1.76, 95% CI 1.28-2.42, p = 0.0005) and multivariate analyses (HR 1.46, 95% CI 1.05-2.04, p = 0.0257). Conclusions: Adipophilin is a novel and still understudied prognostic biomarker in clear cell renal cell carcinoma which deserves further study. Twit Text FOAVip Adipophilin as prognostic biomarker in clear cell renal cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28404922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28404922 #FOAvip English Wikipedia <ref>{{Cite pmid|28404922}}</ref> Adipophilin as prognostic biomarker in clear cell renal cell carcinoma #MMPMID28404922 Tolkach Y; Lüders C; Meller S; Jung K; Stephan C; Kristiansen G Oncotarget 2017[Apr]; 8 (17): 28672-82 PMID28404922show ga Objective: To study the expression of adipophilin (PLIN2), a lipid storage-associated cell protein, in different subtypes of renal cell cancer and to elucidate its prognostic value. Materials and Methods: Two-hundred-seventy-five patients with renal cell carcinoma (RCC) were included in this study. Immunohistochemistry with a polyclonal antibody to adipophilin was used on the tissue microarray (formalin-fixed, paraffin-embedded tissue) for detection of adipophilin. Median follow-up time was 91 (range 1-159) months in the whole cohort and 100 (1-159) months for patients with clear-cell RCC. Additional validation for adipophilin was performed using publicly available gene expression data for clear cell RCC from The Cancer Genome Atlas (TCGA). Results: Adipophilin expression was detected in 14.3% of papillary RCC, in 0% of chromophobe RCC and in 58.7% of clear-cell RCC in the cytoplasm or at the membrane. Only membrane expression was correlated with other clinical parameters (pT-stage, pN-stage, R-status, sex) and showed a prognostic significance in univariate analysis with regard to overall survival of patients with clear cell subtype (HR 2.90, 95% CI 1.55-5.42, p=0.001), which failed significance on multivariate analysis. mRNA expression of PLIN2 on TCGA data using best selected cut-off was prognostically significant in both univariate (HR 1.76, 95% CI 1.28-2.42, p = 0.0005) and multivariate analyses (HR 1.46, 95% CI 1.05-2.04, p = 0.0257). Conclusions: Adipophilin is a novel and still understudied prognostic biomarker in clear cell renal cell carcinoma which deserves further study. äAdipophilin as prognostic biomarker in clear cell renal cell carcinoma(epmc).pdf DeepDyve Pubget Overpricing