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10.18632/oncotarget.15891 http://scihub22266oqcxt.onion/10.18632/oncotarget.15891 C5438634!5438634 !28427212     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28427212 &cmd=llinks): Failed to open stream: HTTP request failed! 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High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer |pdf=|usr=}}{{28427212 }} gab.com Text High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28427212 #FOAvip We have previously identified a novel intra-tumoral dichotomy in triple-negative breast cancer (TNBC) based on the differential responsiveness to a reporter containing the Sox2 regulatory region-2 (SRR2), with reporter responsive (RR) cells being more stem-like than reporter unresponsive (RU) cells. Using bioinformatics, we profiled the protein-DNA binding motifs of SRR2 and identified Myc as one of the potential transcription factors driving SRR2 activity. In support of its role, Myc was found to be highly expressed in RR cells as compared to RU cells. Enforced expression of MYC in RU cells resulted in a significant increase in SRR2 activity, Myc-DNA binding, proportion of cellsexpressing CD44+/CD24-, chemoresistance and mammosphere formation. Knockdown of Myc using siRNA in RR cells led to the opposite effects. We also found evidence that the relatively high ERK activation in RR cells contributes to their high expression of Myc and stem-like features. Using confocal microscopy and patient samples, we found a co-localization between Myc and CD44 in the same cell population. Lastly, a high proportion of Myc-positive cells in tumors significantly correlated with a short patient survival. In conclusion, inhibition of the MAPK/ERK/Myc axis may be an effective approach in eliminating stem-like cells in TNBC. Twit Text FOAVip High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28427212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427212 #FOAvip English Wikipedia <ref>{{Cite pmid|28427212 }}</ref> High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer #MMPMID28427212 Gupta N ; Jung K ; Wu C ; Alshareef A ; Alqahtani H ; Damaraju S ; Mackey JR ; Ghosh S ; Sabri S ; Abdulkarim BS ; Bigras G ; Lai R Oncotarget 2017[Apr]; 8 (17 ): 28101-28115 PMID28427212 show ga We have previously identified a novel intra-tumoral dichotomy in triple-negative breast cancer (TNBC) based on the differential responsiveness to a reporter containing the Sox2 regulatory region-2 (SRR2), with reporter responsive (RR) cells being more stem-like than reporter unresponsive (RU) cells. Using bioinformatics, we profiled the protein-DNA binding motifs of SRR2 and identified Myc as one of the potential transcription factors driving SRR2 activity. In support of its role, Myc was found to be highly expressed in RR cells as compared to RU cells. Enforced expression of MYC in RU cells resulted in a significant increase in SRR2 activity, Myc-DNA binding, proportion of cellsexpressing CD44+/CD24-, chemoresistance and mammosphere formation. Knockdown of Myc using siRNA in RR cells led to the opposite effects. We also found evidence that the relatively high ERK activation in RR cells contributes to their high expression of Myc and stem-like features. Using confocal microscopy and patient samples, we found a co-localization between Myc and CD44 in the same cell population. Lastly, a high proportion of Myc-positive cells in tumors significantly correlated with a short patient survival. In conclusion, inhibition of the MAPK/ERK/Myc axis may be an effective approach in eliminating stem-like cells in TNBC. |*Gene Expression Regulation, Neoplastic [MESH] |*Transcriptional Activation [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Expression Profiling [MESH] |Genes, Reporter [MESH] |Humans [MESH] |Hyaluronan Receptors/metabolism [MESH] |MAP Kinase Signaling System [MESH] |Middle Aged [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Neoplastic Stem Cells/metabolism/pathology [MESH] |Prognosis [MESH] |Protein Binding [MESH] |Protein Transport [MESH] |Proto-Oncogene Proteins c-myc/*genetics/*metabolism [MESH]High Myc expression and transcription activity underlies intra-tumoral(epmc).pdf DeepDyve Pubget Overpricing