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10.18632/oncotarget.14611 http://scihub22266oqcxt.onion/10.18632/oncotarget.14611 C5438601!5438601 !28099913     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28099913 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (17 ): 27693-27703 Nephropedia Template TP {{tp|p=28099913 |t=2017. ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats |pdf=|usr=}}{{28099913 }} gab.com Text ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099913 #FOAvip Numerous researches supported that microbiota can influence behavior and modulate cognitive function through "microbiota-gut-brain" axis. Our previous study has demonstrated that ZiBuPiYin recipe (ZBPYR) possesses excellent pharmacological effects against diabetes-associated cognitive decline. To elucidate the role of ZBPYR in regulating the balance of gut microbiota to improve psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we compared blood glucose, behavioral and cognitive functions and diversity of the bacterial community among experimental groups. The Zucker diabetic fatty (ZDF) rats with PSDACD exhibited behavioral and cognitive anomalies showing as increased anxiety- and depression-like behaviors and decreased learning and memory abilities. High-throughput sequencing of the bacterial 16S rRNA gene revealed that Roseburia and Coprococcus were decreased in ZDF rats with PSDACD compared with control group. Notably, these changes were reversed by ZBPYR treatment. Our findings indicate that ZBPYR might prevent PSDACD by maintaining the compositions of gut microbiota, which could be developed as a new therapy for T2D with PSDACD. Twit Text FOAVip ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099913 #FOAvip English Wikipedia <ref>{{Cite pmid|28099913 }}</ref> ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats #MMPMID28099913 Gu C ; Zhou W ; Wang W ; Xiang H ; Xu H ; Liang L ; Sui H ; Zhan L ; Lu X Oncotarget 2017[Apr]; 8 (17 ): 27693-27703 PMID28099913 show ga Numerous researches supported that microbiota can influence behavior and modulate cognitive function through "microbiota-gut-brain" axis. Our previous study has demonstrated that ZiBuPiYin recipe (ZBPYR) possesses excellent pharmacological effects against diabetes-associated cognitive decline. To elucidate the role of ZBPYR in regulating the balance of gut microbiota to improve psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we compared blood glucose, behavioral and cognitive functions and diversity of the bacterial community among experimental groups. The Zucker diabetic fatty (ZDF) rats with PSDACD exhibited behavioral and cognitive anomalies showing as increased anxiety- and depression-like behaviors and decreased learning and memory abilities. High-throughput sequencing of the bacterial 16S rRNA gene revealed that Roseburia and Coprococcus were decreased in ZDF rats with PSDACD compared with control group. Notably, these changes were reversed by ZBPYR treatment. Our findings indicate that ZBPYR might prevent PSDACD by maintaining the compositions of gut microbiota, which could be developed as a new therapy for T2D with PSDACD. |Animals [MESH] |Bacteria/*drug effects/genetics/isolation & purification [MESH] |Blood Glucose/analysis [MESH] |Cognition/drug effects [MESH] |Cognitive Dysfunction/blood/*drug therapy/etiology [MESH] |Diabetes Mellitus, Type 2/blood/complications/*drug therapy/genetics [MESH] |Disease Models, Animal [MESH] |Drugs, Chinese Herbal/pharmacology/*therapeutic use [MESH] |Gastrointestinal Microbiome/*drug effects [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Intestinal Mucosa/microbiology [MESH] |Male [MESH] |Maze Learning/drug effects [MESH] |Medicine, Chinese Traditional [MESH] |Mutation [MESH] |RNA, Ribosomal, 16S/*isolation & purification [MESH] |Rats [MESH] |Rats, Zucker [MESH] |Receptors, Leptin/genetics [MESH] |Sequence Analysis, RNA [MESH] |Spatial Memory/drug effects [MESH]ZiBuPiYin recipe improves cognitive decline by regulating gut microbio(epmc).pdf DeepDyve Pubget Overpricing