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10.1186/s12864-017-3785-4 http://scihub22266oqcxt.onion/10.1186/s12864-017-3785-4 C5438547!5438547!28525990     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Genomics 2017 ; 18 (ä): ä Nephropedia Template TP {{tp|p=28525990|t=2017. Transversions have larger regulatory effects than transitions |pdf=|usr=}}{{28525990}} gab.com Text Transversions have larger regulatory effects than transitions JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28525990 #FOAvip Background: Transversions (Tv?s) are more likely to alter the amino acid sequence of proteins than transitions (Ts?s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the two different types of mutations have different effects in non-protein-coding sequences remains unknown. Genetic variants primarily impact gene expression by disrupting the binding of transcription factors (TFs) and other DNA-binding proteins. Because Tv?s cause larger changes in the shape of a DNA backbone, we hypothesized that Tv?s would have larger impacts on TF binding and gene expression. Results: Here, we provide multiple lines of evidence demonstrating that Tv?s have larger impacts on regulatory DNA including analyses of TF binding motifs and allele-specific TF binding. In these analyses, we observed a depletion of Tv?s within TF binding motifs and TF binding sites. Using massively parallel population-scale reporter assays, we also provided empirical evidence that Tv?s have larger effects than Ts?s on the activity of human gene regulatory elements. Conclusions: Tv?s are more likely to disrupt TF binding, resulting in larger changes in gene expression. Although the observed differences are small, these findings represent a novel, fundamental property of regulatory variation. Understanding the features of functional non-coding variation could be valuable for revealing the genetic underpinnings of complex traits and diseases in future studies. Electronic supplementary material: The online version of this article (doi:10.1186/s12864-017-3785-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Transversions have larger regulatory effects than transitions ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28525990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28525990 #FOAvip English Wikipedia <ref>{{Cite pmid|28525990}}</ref> Transversions have larger regulatory effects than transitions #MMPMID28525990 Guo C; McDowell IC; Nodzenski M; Scholtens DM; Allen AS; Lowe WL; Reddy TE BMC Genomics 2017[]; 18 (ä): ä PMID28525990show ga Background: Transversions (Tv?s) are more likely to alter the amino acid sequence of proteins than transitions (Ts?s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the two different types of mutations have different effects in non-protein-coding sequences remains unknown. Genetic variants primarily impact gene expression by disrupting the binding of transcription factors (TFs) and other DNA-binding proteins. Because Tv?s cause larger changes in the shape of a DNA backbone, we hypothesized that Tv?s would have larger impacts on TF binding and gene expression. Results: Here, we provide multiple lines of evidence demonstrating that Tv?s have larger impacts on regulatory DNA including analyses of TF binding motifs and allele-specific TF binding. In these analyses, we observed a depletion of Tv?s within TF binding motifs and TF binding sites. Using massively parallel population-scale reporter assays, we also provided empirical evidence that Tv?s have larger effects than Ts?s on the activity of human gene regulatory elements. Conclusions: Tv?s are more likely to disrupt TF binding, resulting in larger changes in gene expression. Although the observed differences are small, these findings represent a novel, fundamental property of regulatory variation. Understanding the features of functional non-coding variation could be valuable for revealing the genetic underpinnings of complex traits and diseases in future studies. Electronic supplementary material: The online version of this article (doi:10.1186/s12864-017-3785-4) contains supplementary material, which is available to authorized users. äTransversions have larger regulatory effects than transitions (epmc).pdf DeepDyve Pubget Overpricing