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10.1038/s41598-017-02080-w http://scihub22266oqcxt.onion/10.1038/s41598-017-02080-w C5438352!5438352 !28526884     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28526884 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 2169 Nephropedia Template TP {{tp|p=28526884 |t=2017. Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet |pdf=|usr=}}{{28526884 }} gab.com Text Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28526884 #FOAvip Statins are widely used to reduce cardiovascular risk. Unfortunately, some patients still experience cardiovascular events though prescribed with high-intensity statins. Metformin, an anti-diabetic drug, was reported to possess anti-atherosclerotic effects. Therefore, the experiments were designed to evaluate whether combined use of metformin and atorvastatin can achieve additional benefits. In rabbits fed a high-cholesterol diet, we evaluated the effects of the combination therapy on atherosclerotic plaques, lipid profiles, blood glucose levels, liver and kidney functions. Effects of combination therapy on cholesterol efflux and the expression of related transporters were studied in vitro. Our results showed that the combination therapy induced a more significant decrease in atherosclerotic lesion area than atorvastatin without additional lipid-lowering effect. The combination therapy significantly increased the percentage of large high-density lipoprotein subfraction. The intravenous glucose tolerance test showed that atorvastatin-treated rabbits had an increased area under the curve for time-dependent glucose levels after a bolus injection of glucose, which was completely reversed by metformin treatment. In cultured macrophages, co-treatment with metformin and atorvastatin promoted cholesterol efflux and up-regulated expression of ATP-binding cassette transporters A1 and G1. Taken together, our results suggest that atorvastatin/metformin combination therapy may achieve additional anti-atherosclerotic benefits likely through increasing cholesterol efflux in macrophages. Twit Text FOAVip Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28526884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28526884 #FOAvip English Wikipedia <ref>{{Cite pmid|28526884 }}</ref> Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet #MMPMID28526884 Luo F ; Guo Y ; Ruan GY ; Long JK ; Zheng XL ; Xia Q ; Zhao SP ; Peng DQ ; Fang ZF ; Li XP Sci Rep 2017[May]; 7 (1 ): 2169 PMID28526884 show ga Statins are widely used to reduce cardiovascular risk. Unfortunately, some patients still experience cardiovascular events though prescribed with high-intensity statins. Metformin, an anti-diabetic drug, was reported to possess anti-atherosclerotic effects. Therefore, the experiments were designed to evaluate whether combined use of metformin and atorvastatin can achieve additional benefits. In rabbits fed a high-cholesterol diet, we evaluated the effects of the combination therapy on atherosclerotic plaques, lipid profiles, blood glucose levels, liver and kidney functions. Effects of combination therapy on cholesterol efflux and the expression of related transporters were studied in vitro. Our results showed that the combination therapy induced a more significant decrease in atherosclerotic lesion area than atorvastatin without additional lipid-lowering effect. The combination therapy significantly increased the percentage of large high-density lipoprotein subfraction. The intravenous glucose tolerance test showed that atorvastatin-treated rabbits had an increased area under the curve for time-dependent glucose levels after a bolus injection of glucose, which was completely reversed by metformin treatment. In cultured macrophages, co-treatment with metformin and atorvastatin promoted cholesterol efflux and up-regulated expression of ATP-binding cassette transporters A1 and G1. Taken together, our results suggest that atorvastatin/metformin combination therapy may achieve additional anti-atherosclerotic benefits likely through increasing cholesterol efflux in macrophages. |Animals [MESH] |Atherosclerosis/drug therapy/*etiology/*metabolism/pathology [MESH] |Atorvastatin/*pharmacology [MESH] |Biomarkers [MESH] |Biopsy [MESH] |Cholesterol/*metabolism [MESH] |Diet, High-Fat/*adverse effects [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Immunohistochemistry [MESH] |Lipid Metabolism/drug effects [MESH] |Male [MESH] |Metformin/*pharmacology [MESH] |Plaque, Atherosclerotic/drug therapy/metabolism/pathology [MESH]Combined use of metformin and atorvastatin attenuates atherosclerosis (epmc).pdf DeepDyve Pubget Overpricing