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10.1038/s41598-017-02257-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-02257-3 C5438348!5438348 !28526829     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28526829 &cmd=llinks): Failed to open stream: HTTP request failed! 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Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions |pdf=|usr=}}{{28526829 }} gab.com Text Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28526829 #FOAvip Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhancers that overlap with broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes. Besides cell lines, we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human samples. Several chromatin interactions involving super-enhancers and broad H3K4me3 domains are constitutive and can be found in both cancer and normal samples. Taken together, these results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains. Twit Text FOAVip Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28526829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28526829 #FOAvip English Wikipedia <ref>{{Cite pmid|28526829 }}</ref> Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions #MMPMID28526829 Cao F ; Fang Y ; Tan HK ; Goh Y ; Choy JYH ; Koh BTH ; Hao Tan J ; Bertin N ; Ramadass A ; Hunter E ; Green J ; Salter M ; Akoulitchev A ; Wang W ; Chng WJ ; Tenen DG ; Fullwood MJ Sci Rep 2017[May]; 7 (1 ): 2186 PMID28526829 show ga Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhancers that overlap with broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes. Besides cell lines, we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human samples. Several chromatin interactions involving super-enhancers and broad H3K4me3 domains are constitutive and can be found in both cancer and normal samples. Taken together, these results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains. |*Enhancer Elements, Genetic [MESH] |*Gene Expression Regulation [MESH] |*Protein Interaction Domains and Motifs [MESH] |Chromatin/*genetics/*metabolism [MESH] |Histones/chemistry/*metabolism [MESH] |Humans [MESH]Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory(epmc).pdf DeepDyve Pubget Overpricing