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10.7759/cureus.1177 http://scihub22266oqcxt.onion/10.7759/cureus.1177 C5438231!5438231!28533995     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cureus ä ; 9 (4): ä Nephropedia Template TP {{tp|p=28533995|t=ä. Crohn?s Disease and Ulcerative Colitis Show Unique Cytokine Profiles |pdf=|usr=}}{{28533995}} gab.com Text Crohn s Disease and Ulcerative Colitis Show Unique Cytokine Profiles JO: Cureus http://www.kidney.de/pget.php?&tw=1&pmid=28533995 #FOAvip Introduction: Networks of cytokines have been implicated in both forms of inflammatory bowel disease (IBD): Crohn?s disease (CD) and ulcerative colitis (UC). While CD has associated with T-helper type 1 (Th1) immune responses, UC shows Th2 patterns. Recent studies reported that the inflamed intestinal regions in both CD and UC are significantly infiltrated with a newly described set of T helper, the Th17 cells. These cells have unique cytokine responses. These findings prompted us to further explore the cytokine profiles of CD and UC with a special focus on the Th2 and Th17 related mediators. Methods: Cytokine transcripts were compared using real-time polymerase chain reaction (PCR) in both inflamed and non-inflamed mucosal specimens from patients with active CD (n=35) or UC (n=20) and without CD or UC (Control, n=54). Results: In both CD and UC, interleukin (IL)-12 (p40), IL-18, IL-21 and IL-27 transcript levels were higher than in Control. The highest levels of cytokines were found in the diseased areas of CD and UC with only one exception; IL-12 (p40) in CD was more up-regulated in the non-diseased areas compared to diseased CD and Control specimens. CD samples but not UC specimens showed significant IL-17, IL-23, and IL-32 mRNA expression indicating a trend toward Th17 responses. In UC, however, IL-5, IL-13, IL-15 and IL-33 mRNA levels were significantly increased when compared to both CD and Control. Conclusions: The unique patterns of cytokine networks can help us to better understand the differential expression of their characteristic pathophysiology. In addition, the pharmacological regulation of these small molecules may hold promise to more effective and personalized therapies. Twit Text FOAVip Crohn s Disease and Ulcerative Colitis Show Unique Cytokine Profiles ????Cureus http://www.kidney.de/pget.php?&tw=1&pmid=28533995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28533995 #FOAvip English Wikipedia <ref>{{Cite pmid|28533995}}</ref> Crohn?s Disease and Ulcerative Colitis Show Unique Cytokine Profiles #MMPMID28533995 Nemeth ZH; Bogdanovski DA; Barratt-Stopper P; Paglinco SR; Antonioli L; Rolandelli RH Cureus ä[]; 9 (4): ä PMID28533995show ga Introduction: Networks of cytokines have been implicated in both forms of inflammatory bowel disease (IBD): Crohn?s disease (CD) and ulcerative colitis (UC). While CD has associated with T-helper type 1 (Th1) immune responses, UC shows Th2 patterns. Recent studies reported that the inflamed intestinal regions in both CD and UC are significantly infiltrated with a newly described set of T helper, the Th17 cells. These cells have unique cytokine responses. These findings prompted us to further explore the cytokine profiles of CD and UC with a special focus on the Th2 and Th17 related mediators. Methods: Cytokine transcripts were compared using real-time polymerase chain reaction (PCR) in both inflamed and non-inflamed mucosal specimens from patients with active CD (n=35) or UC (n=20) and without CD or UC (Control, n=54). Results: In both CD and UC, interleukin (IL)-12 (p40), IL-18, IL-21 and IL-27 transcript levels were higher than in Control. The highest levels of cytokines were found in the diseased areas of CD and UC with only one exception; IL-12 (p40) in CD was more up-regulated in the non-diseased areas compared to diseased CD and Control specimens. CD samples but not UC specimens showed significant IL-17, IL-23, and IL-32 mRNA expression indicating a trend toward Th17 responses. In UC, however, IL-5, IL-13, IL-15 and IL-33 mRNA levels were significantly increased when compared to both CD and Control. Conclusions: The unique patterns of cytokine networks can help us to better understand the differential expression of their characteristic pathophysiology. In addition, the pharmacological regulation of these small molecules may hold promise to more effective and personalized therapies. äCrohn?s Disease and Ulcerative Colitis Show Unique Cytokine Profiles (epmc).pdf DeepDyve Pubget Overpricing