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10.1186/s12882-017-0572-z http://scihub22266oqcxt.onion/10.1186/s12882-017-0572-z C5437587!5437587 !28521802     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28521802 &cmd=llinks): Failed to open stream: HTTP request failed! 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Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study |pdf=|usr=}}{{28521802 }} gab.com Text Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28521802 #FOAvip BACKGROUND: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD. METHODS: This was a single-center, retrospective, follow-up study. One-hundred and seventy-eight CKD patients with hyperuricemia who received febuxostat therapy were included in this study. Mean serum uric acid (mUA) level after treatment and changes in estimated glomerular filtration rate (?eGFR) over 6 months were measured and their correlation was examined. Patients were divided into two groups based on mUA, and their ?eGFR were compared. These analyses were evaluated in various subgroups. RESULTS: Febuxostat therapy markedly decreased UA level in any CKD stage patients without resulting in serious adverse events. eGFRs of CKD patients in the mUA < 6.0 mg/dl group were maintained, whereas those in the mUA ? 6.0 mg/dl group decreased. A significant inverse correlation was observed between mUA and ?eGFR (r = -0.16, p = 0.019). The renoprotective effects of febuxostat were significant in the following subgroups: male patients, age < 70 years, systolic blood pressure < 130 mmHg, normal cholesterol levels, and absence of diabetes. Coexisting vascular risk factors appear to exert additive masking effects against febuxostat renoprotection. CONCLUSIONS: The results of this study suggest that various vascular risk factors markedly attenuate the renoprotective effects of febuxostat. Twit Text FOAVip Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28521802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28521802 #FOAvip English Wikipedia <ref>{{Cite pmid|28521802 }}</ref> Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study #MMPMID28521802 Yamaguchi A ; Harada M ; Yamada Y ; Hashimoto K ; Kamijo Y BMC Nephrol 2017[May]; 18 (1 ): 162 PMID28521802 show ga BACKGROUND: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD. METHODS: This was a single-center, retrospective, follow-up study. One-hundred and seventy-eight CKD patients with hyperuricemia who received febuxostat therapy were included in this study. Mean serum uric acid (mUA) level after treatment and changes in estimated glomerular filtration rate (?eGFR) over 6 months were measured and their correlation was examined. Patients were divided into two groups based on mUA, and their ?eGFR were compared. These analyses were evaluated in various subgroups. RESULTS: Febuxostat therapy markedly decreased UA level in any CKD stage patients without resulting in serious adverse events. eGFRs of CKD patients in the mUA < 6.0 mg/dl group were maintained, whereas those in the mUA ? 6.0 mg/dl group decreased. A significant inverse correlation was observed between mUA and ?eGFR (r = -0.16, p = 0.019). The renoprotective effects of febuxostat were significant in the following subgroups: male patients, age < 70 years, systolic blood pressure < 130 mmHg, normal cholesterol levels, and absence of diabetes. Coexisting vascular risk factors appear to exert additive masking effects against febuxostat renoprotection. CONCLUSIONS: The results of this study suggest that various vascular risk factors markedly attenuate the renoprotective effects of febuxostat. |Adolescent [MESH] |Adult [MESH] |Age Distribution [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Comorbidity [MESH] |Febuxostat/*therapeutic use [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Glomerular Filtration Rate/drug effects [MESH] |Humans [MESH] |Hyperuricemia/*drug therapy/*epidemiology/prevention & control [MESH] |Japan/epidemiology [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Middle Aged [MESH] |Prevalence [MESH] |Renal Agents/therapeutic use [MESH] |Renal Insufficiency, Chronic/diagnosis/*drug therapy/*epidemiology [MESH] |Retrospective Studies [MESH] |Risk Factors [MESH] |Sex Distribution [MESH] |Treatment Outcome [MESH] |Uric Acid/blood [MESH] |Vascular Diseases/diagnosis/*epidemiology [MESH]Identification of chronic kidney disease patient characteristics influ(epmc).pdf DeepDyve Pubget Overpricing