Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study
in an Atherosclerotic Model
#MMPMID28364193
Ellenbroek GHJM
; van Hout GPJ
; de Jager SCA
; Timmers L
; Vink A
; Goldschmeding R
; van der Kraak P
; Pasterkamp G
; Hoefer IE
; Doevendans PA
; Appelman Y
J Cardiovasc Transl Res
2017[Apr]; 10
(2
): 221-232
PMID28364193
show ga
Increased plaque vascularization is causatively associated with the progression
of unstable atherosclerotic vessel disease. We investigated the safety and
efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number
of vessels in the plaque and adventitia and its effect on plaque size and
composition. To this end, New Zealand White rabbits were fed a
cholesterol-enriched diet and subjected to balloon denudation of the infrarenal
aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or
distal half of the infrarenal aorta was exposed to transluminal RFA. The
untreated half served as an intra-individual control. Optical coherence
tomography (OCT) was performed directly after RFA. We found that RFA on the
rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel
density and smooth muscle cell content but does not affect other components of
plaque composition or size.
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