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10.1038/onc.2016.436 http://scihub22266oqcxt.onion/10.1038/onc.2016.436 C5436952!5436952!27991924     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2017 ; 36 (20): 2846-56 Nephropedia Template TP {{tp|p=27991924|t=2017. COOPERATION AMONG HETEROGENEOUS PROSTATE CANCER CELLS IN THE BONE METASTATIC NICHE |pdf=|usr=}}{{27991924}} gab.com Text COOPERATION AMONG HETEROGENEOUS PROSTATE CANCER CELLS IN THE BONE METASTATIC NICHE JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=27991924 #FOAvip The growth of disseminated tumor cells (DTCs) into metastatic lesions depends on the establishment of a favorable microenvironment in the stroma of the target organs. Here we show that mice treated with anakinra, an antagonist of the IL-1? receptor (IL-1R), or harboring a targeted deletion of IL-1R are significantly less prone to develop bone tumors when inoculated in the arterial circulation with human prostate cancer (PCa) cells expressing IL-1?. Interestingly, human mesenchymal stem cells (hMSCs) exposed in vitro to medium conditioned by IL-1?-expressing cancer cells responded by up regulating S100A4, a marker of cancer-associated fibroblasts (CAFs), and this effect was blocked by anakinra. Analogously, the stroma adjacent to skeletal metastases generated in mice by IL-1?-expressing cancer cells showed a dramatic increase in S100A4, COX-2 and the alteration of thirty tumor-related genes as measured by Nanostring analysis. These effects were not observed in the stroma associated to the rare and much smaller metastases generated by the same cells in IL-1R knockout animals, confirming that tumor-secreted IL-1? generates skeletal CAFs and conditions the surrounding bone microenvironment. In skeletal lesions from patients with metastatic PCa, histological and molecular analyses revealed that IL-1? is highly expressed in cancer cells in which the androgen receptor (AR) is not detected (AR?) whereas this cytokine is uniformly absent in the AR-positive (AR+) metastatic cells. The stroma conditioned by IL-1?-expressing cancer cells served as a supportive niche also for coexisting IL-1?-lacking cancer cells, which are otherwise unable to generate tumors after independently seeding the skeleton of mice. This niche is established very early following tumor seeding and hints to a role of IL-1? in promoting early colonization of PCa at the skeletal level. Twit Text FOAVip COOPERATION AMONG HETEROGENEOUS PROSTATE CANCER CELLS IN THE BONE METASTATIC NICHE ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=27991924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27991924 #FOAvip English Wikipedia <ref>{{Cite pmid|27991924}}</ref> COOPERATION AMONG HETEROGENEOUS PROSTATE CANCER CELLS IN THE BONE METASTATIC NICHE #MMPMID27991924 Shahriari K; Shen F; Worrede-Mahdi A; Liu Q; Gong Y; Garcia FU; Fatatis A Oncogene 2017[May]; 36 (20): 2846-56 PMID27991924show ga The growth of disseminated tumor cells (DTCs) into metastatic lesions depends on the establishment of a favorable microenvironment in the stroma of the target organs. Here we show that mice treated with anakinra, an antagonist of the IL-1? receptor (IL-1R), or harboring a targeted deletion of IL-1R are significantly less prone to develop bone tumors when inoculated in the arterial circulation with human prostate cancer (PCa) cells expressing IL-1?. Interestingly, human mesenchymal stem cells (hMSCs) exposed in vitro to medium conditioned by IL-1?-expressing cancer cells responded by up regulating S100A4, a marker of cancer-associated fibroblasts (CAFs), and this effect was blocked by anakinra. Analogously, the stroma adjacent to skeletal metastases generated in mice by IL-1?-expressing cancer cells showed a dramatic increase in S100A4, COX-2 and the alteration of thirty tumor-related genes as measured by Nanostring analysis. These effects were not observed in the stroma associated to the rare and much smaller metastases generated by the same cells in IL-1R knockout animals, confirming that tumor-secreted IL-1? generates skeletal CAFs and conditions the surrounding bone microenvironment. In skeletal lesions from patients with metastatic PCa, histological and molecular analyses revealed that IL-1? is highly expressed in cancer cells in which the androgen receptor (AR) is not detected (AR?) whereas this cytokine is uniformly absent in the AR-positive (AR+) metastatic cells. The stroma conditioned by IL-1?-expressing cancer cells served as a supportive niche also for coexisting IL-1?-lacking cancer cells, which are otherwise unable to generate tumors after independently seeding the skeleton of mice. This niche is established very early following tumor seeding and hints to a role of IL-1? in promoting early colonization of PCa at the skeletal level. äCOOPERATION AMONG HETEROGENEOUS PROSTATE CANCER CELLS IN THE BONE META(epmc).pdf DeepDyve Pubget Overpricing