Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28542623
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28542623
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2017 ; 12
(5
): e0177987
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Gallium nanoparticles facilitate phagosome maturation and inhibit growth of
virulent Mycobacterium tuberculosis in macrophages
#MMPMID28542623
Choi SR
; Britigan BE
; Moran DM
; Narayanasamy P
PLoS One
2017[]; 12
(5
): e0177987
PMID28542623
show ga
New treatments and novel drugs are required to counter the growing problem of
drug-resistant strains of Mycobacterium tuberculosis (M.tb). Our approach against
drug resistant M.tb, as well as other intracellular pathogens, is by targeted
drug delivery using nanoformulations of drugs already in use, as well as drugs in
development. Among the latter are gallium (III) (Ga)-based compounds. In the
current work, six different types of Ga and rifampin nanoparticles were prepared
in such a way as to enhance targeting of M.tb infected-macrophages. They were
then tested for their ability to inhibit growth of a fully pathogenic strain
(H37Rv) or a non-pathogenic strain (H37Ra) of M.tb. Encapsulating Ga in folate-
or mannose-conjugated block copolymers provided sustained Ga release for 15 days
and significantly inhibited M.tb growth in human monocyte-derived macrophages.
Nanoformulations with dendrimers encapsulating Ga or rifampin also showed
promising anti-tuberculous activity. The nanoparticles co-localized with M.tb
containing phagosomes, as measured by detection of mature cathepsin D (34 kDa,
lysosomal hydrogenase). They also promoted maturation of the phagosome, which
would be expected to increase macrophage-mediated killing of the organism.
Delivery of Ga or rifampin in the form of nanoparticles to macrophages offers a
promising approach for the development of new therapeutic anti-tuberculous drugs.
free
free
free
