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10.2147/IJNRD.S126844

http://scihub22266oqcxt.onion/10.2147/IJNRD.S126844
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C5436760!5436760!28546764
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suck abstract from ncbi


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pmid28546764      Int+J+Nephrol+Renovasc+Dis 2017 ; 10 (ä): 97-107
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  • Optimal management of primary focal segmental glomerulosclerosis in adults #MMPMID28546764
  • Beaudreuil S; Lorenzo HK; Elias M; Nnang Obada E; Charpentier B; Durrbach A
  • Int J Nephrol Renovasc Dis 2017[]; 10 (ä): 97-107 PMID28546764show ga
  • Focal segmental glomerulosclerosis (FSGS) is a frequent glomerular kidney disease that is revealed by proteinuria or even nephrotic syndrome. A diagnosis can be established from a kidney biopsy that shows focal and segmental glomerulosclerosis. This histopathological lesion may be caused by a primary podocyte injury (idiopathic FSGS) but is also associated with other pathologies (secondary FSGS). The first-line treatment for idiopathic FSGS with nephrotic syndrome is a prolonged course of corticosteroids. However, steroid resistance or steroid dependence is frequent, and despite intensified immunosuppressive treatment, FSGS can lead to end-stage renal failure. In addition, in some cases, FSGS can recur on a graft after kidney transplantation: an unidentified circulating factor may be implicated. Understanding of its physiopathology is unclear, and it remains an important challenge for the scientific community to identify a specific diagnostic biomarker and to develop specific therapeutics. This study reviews the treatment of primary FSGS and the recurrence of FSGS after kidney transplantation in adults.
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