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10.4103/1673-5374.205083 http://scihub22266oqcxt.onion/10.4103/1673-5374.205083 C5436342!5436342!28553324     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neural+Regen+Res 2017 ; 12 (4): 538-48 Nephropedia Template TP {{tp|p=28553324|t=2017. The complexities underlying age-related macular degeneration: could amyloid beta play an important role?|pdf=|usr=}}{{28553324}} gab.com Text The complexities underlying age-related macular degeneration: could amyloid beta play an important role JO: Neural Regen Res http://www.kidney.de/pget.php?&tw=1&pmid=28553324 #FOAvip Age-related macular degeneration (AMD) causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer's-linked amyloid beta (A?) group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer's disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that A? fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of A? were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of A? accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of A?-mediated retinopathy. Furthermore, we discuss our findings revealing how A? behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose A? as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for late-stage AMD. Twit Text FOAVip The complexities underlying age-related macular degeneration: could amyloid beta play an important role ????Neural Regen Res http://www.kidney.de/pget.php?&tw=1&pmid=28553324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28553324 #FOAvip English Wikipedia <ref>{{Cite pmid|28553324}}</ref> The complexities underlying age-related macular degeneration: could amyloid beta play an important role? #MMPMID28553324 Lynn SA; Keeling E; Munday R; Gabha G; Griffiths H; Lotery AJ; Ratnayaka JA Neural Regen Res 2017[Apr]; 12 (4): 538-48 PMID28553324show ga Age-related macular degeneration (AMD) causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer's-linked amyloid beta (A?) group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer's disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that A? fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of A? were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of A? accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of A?-mediated retinopathy. Furthermore, we discuss our findings revealing how A? behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose A? as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for late-stage AMD. äThe complexities underlying age-related macular degeneration: could am(epmc).pdf DeepDyve Pubget Overpricing