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The Role of Bone Scintigraphy with Single-photon Emission Computed
Tomography-computed Tomography in the Diagnosis and Evaluation of Calciphylaxis
#MMPMID28553189
Martineau P
; Pelletier-Galarneau M
; Bazarjani S
World J Nucl Med
2017[Apr]; 16
(2
): 172-174
PMID28553189
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Calciphylaxis, also known as calcific uremic arteriolopathy, is an uncommon
disease, typically found in patients with the end-stage renal disease.
Pathophysiological features include small vessel vasculopathy with mural
calcification, fibrosis, and thrombosis. The clinical presentation varies but
often consists of the necrosis of skin and subcutaneous tissues, with or without
visceral organ involvement due to small vessel vasculopathy. This condition has a
significant morbidity and mortality, making accurate diagnosis imperative. We
present a case of calciphylaxis investigated using planar bone scintigraphy and
single-photon emission computed tomography-computed tomography (SPECT-CT). This
case stresses the value of SPECT-CT to accurately localize the abnormal uptake in
subcutaneous soft tissue microcalcifications and confirms the exact location and
extent of pathology.
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