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10.3892/mmr.2017.6437 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6437 C5436288!5436288!28393182     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med+Rep 2017 ; 15 (6): 3467-72 Nephropedia Template TP {{tp|p=28393182|t=2017. Expression of TGF-?1/mTOR signaling pathway in pathological scar fibroblasts |pdf=|usr=}}{{28393182}} gab.com Text Expression of TGF- 1/mTOR signaling pathway in pathological scar fibroblasts JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28393182 #FOAvip The aim of the present study was to detect the expression of the key molecules, including transforming growth factor-?1 (TGF-?1), phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) of TGF-?1/mammalian target of rapamycin (mTOR) pathway in pathological scar fibroblasts. Immunofluorescence, reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis were used to detect the expression of the key molecules TGF-?1, PI3K, Akt, mTOR in fibroblasts of normal skin tissue and pathological scar tissue. Immunofluorescence showed that the expression of TGF-?1, PI3K and Akt was significantly enhanced (P<0.05) in pathological scar fibroblasts, and mainly expressed in the cell nucleus, but not in normal skin tissue or fibroblasts. RT-PCR and western blot test results revealed that the TGF-?1, PI3K, Akt, and mTOR mRNA and protein expression in pathological scar fibroblasts were significantly higher (P<0.05) than in the normal skin tissue. Expression of the TGF-?1/mTOR signaling pathway in pathological scar fibroblasts was significantly increased. Data suggest that this expression may be an important mechanism for pathological scar formation. Twit Text FOAVip Expression of TGF- 1/mTOR signaling pathway in pathological scar fibroblasts ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28393182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28393182 #FOAvip English Wikipedia <ref>{{Cite pmid|28393182}}</ref> Expression of TGF-?1/mTOR signaling pathway in pathological scar fibroblasts #MMPMID28393182 Zhai XX; Tang ZM; Ding JC; Lu XL Mol Med Rep 2017[Jun]; 15 (6): 3467-72 PMID28393182show ga The aim of the present study was to detect the expression of the key molecules, including transforming growth factor-?1 (TGF-?1), phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) of TGF-?1/mammalian target of rapamycin (mTOR) pathway in pathological scar fibroblasts. Immunofluorescence, reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis were used to detect the expression of the key molecules TGF-?1, PI3K, Akt, mTOR in fibroblasts of normal skin tissue and pathological scar tissue. Immunofluorescence showed that the expression of TGF-?1, PI3K and Akt was significantly enhanced (P<0.05) in pathological scar fibroblasts, and mainly expressed in the cell nucleus, but not in normal skin tissue or fibroblasts. RT-PCR and western blot test results revealed that the TGF-?1, PI3K, Akt, and mTOR mRNA and protein expression in pathological scar fibroblasts were significantly higher (P<0.05) than in the normal skin tissue. Expression of the TGF-?1/mTOR signaling pathway in pathological scar fibroblasts was significantly increased. Data suggest that this expression may be an important mechanism for pathological scar formation. äExpression of TGF-?1/mTOR signaling pathway in pathological scar fibro(epmc).pdf DeepDyve Pubget Overpricing