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10.1038/ncomms15068 http://scihub22266oqcxt.onion/10.1038/ncomms15068 C5436085!5436085!28485401     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28485401|t=2017. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis |pdf=|usr=}}{{28485401}} gab.com Text Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28485401 #FOAvip Foxp3+ regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affected HSCs or bone marrow cells into Treg-competent recipients. B-cell reconstitution is abrogated in both syngeneic and allogeneic transplantation using Treg-depleted mice as recipients. Treg cells can control physiological IL-7 production that is indispensable for normal B-cell lymphopoiesis and is mainly sustained by a subpopulation of ICAM1+ perivascular stromal cells. Our study demonstrates that Treg cells are important for B-cell differentiation from HSCs by maintaining immunological homoeostasis in the bone marrow microenvironment, both in physiological conditions and after bone marrow transplantation. Twit Text FOAVip Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28485401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28485401 #FOAvip English Wikipedia <ref>{{Cite pmid|28485401}}</ref> Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis #MMPMID28485401 Pierini A; Nishikii H; Baker J; Kimura T; Kwon HS; Pan Y; Chen Y; Alvarez M; Strober W; Velardi A; Shizuru JA; Wu JY; Chiba S; Negrin RS Nat Commun 2017[]; 8 (ä): ä PMID28485401show ga Foxp3+ regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affected HSCs or bone marrow cells into Treg-competent recipients. B-cell reconstitution is abrogated in both syngeneic and allogeneic transplantation using Treg-depleted mice as recipients. Treg cells can control physiological IL-7 production that is indispensable for normal B-cell lymphopoiesis and is mainly sustained by a subpopulation of ICAM1+ perivascular stromal cells. Our study demonstrates that Treg cells are important for B-cell differentiation from HSCs by maintaining immunological homoeostasis in the bone marrow microenvironment, both in physiological conditions and after bone marrow transplantation. äFoxp3+ regulatory T cells maintain the bone marrow microenvironment fo(epmc).pdf DeepDyve Pubget Overpricing