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10.1039/c6cc09770g http://scihub22266oqcxt.onion/10.1039/c6cc09770g C5436042!5436042 !28067354     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28067354 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28067354 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Commun+(Camb) 2017 ; 53 (7 ): 1273-1276 Nephropedia Template TP {{tp|p=28067354 |t=2017. Heparin acts as a structural component of ?-endorphin amyloid fibrils rather than a simple aggregation promoter |pdf=|usr=}}{{28067354 }} gab.com Text Heparin acts as a structural component of -endorphin amyloid fibrils rather than a simple aggregation promoter JO: Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=28067354 #FOAvip The aggregation promoter heparin is commonly used to study the aggregation kinetics and biophysical properties of protein amyloids. However, the underlying mechanism for amyloid promotion by heparin remains poorly understood. In the case of the neuropeptide ?-endorphin that can reversibly adopt a functional amyloid form in nature, aggregation in the presence of heparin leads to a loss of function. Applying correlative optical super-resolution microscopy methods, we show that heparin incorporates into emerging ?-endorphin fibrils forming an integral component and is essential for amyloid templating. This will have direct implications on ?-endorphin's normal physiological function and raises concerns on the biological relevance of heparin-promoted amyloid models. Twit Text FOAVip Heparin acts as a structural component of -endorphin amyloid fibrils rather than a simple aggregation promoter ????Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=28067354 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28067354 #FOAvip English Wikipedia <ref>{{Cite pmid|28067354 }}</ref> Heparin acts as a structural component of ?-endorphin amyloid fibrils rather than a simple aggregation promoter #MMPMID28067354 Nespovitaya N ; Mahou P ; Laine RF ; Schierle GSK ; Kaminski CF Chem Commun (Camb) 2017[Jan]; 53 (7 ): 1273-1276 PMID28067354 show ga The aggregation promoter heparin is commonly used to study the aggregation kinetics and biophysical properties of protein amyloids. However, the underlying mechanism for amyloid promotion by heparin remains poorly understood. In the case of the neuropeptide ?-endorphin that can reversibly adopt a functional amyloid form in nature, aggregation in the presence of heparin leads to a loss of function. Applying correlative optical super-resolution microscopy methods, we show that heparin incorporates into emerging ?-endorphin fibrils forming an integral component and is essential for amyloid templating. This will have direct implications on ?-endorphin's normal physiological function and raises concerns on the biological relevance of heparin-promoted amyloid models. |*Protein Aggregates [MESH] |*Protein Aggregation, Pathological [MESH] |Amyloid beta-Peptides/*chemistry [MESH] |Amyloid/*chemistry [MESH] |Heparin/*chemistry [MESH] |Microscopy [MESH]Heparin acts as a structural component of ?-endorphin amyloid fibrils (epmc).pdf DeepDyve Pubget Overpricing