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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Res+Int 2017 ; 2017 (ä): ä Nephropedia Template TP
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Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis #MMPMID28546962
Sun X; Liu Y; Li C; Wang X; Zhu R; Liu C; Liu H; Wang L; Ma R; Fu M; Zhang D; Li Y
Biomed Res Int 2017[]; 2017 (ä): ä PMID28546962show ga
Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health. Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years. Curcumin exerts antifibrotic effect through reducing inflammation related factors (MCP-1, NF-?B, TNF-?, IL-1?, COX-2, and cav-1) and inducing the expression of anti-inflammation factors (HO-1, M6PRBP1, and NEDD4) as well as targeting TGF-?/Smads, MAPK/ERK, and PPAR-? pathways in animal models. As a food derived compound, curcumin is becoming a promising drug candidate for improving renal health.