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10.1038/s41598-017-02219-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-02219-9 C5435683!5435683 !28515457     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28515457 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 2035 Nephropedia Template TP {{tp|p=28515457 |t=2017. Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex |pdf=|usr=}}{{28515457 }} gab.com Text Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28515457 #FOAvip The Hippo pathway is a tumor suppressor pathway that is implicated in the regulation of organ size. The pathway has three components: the upstream regulatory factors, the kinase core, and the downstream transcriptional machinery, which consists of YAP, TAZ (transcription co-activators) and TEAD (transcription factor). Formation of YAP/TAZ-TEAD complexes leads to the transcription of growth-promoting genes. Herein, we report the crystal structure of TAZ-TEAD4 complex, which reveals two binding modes. The first is similar to the published YAP-TEAD structure. The second is a unique binding mode, whereby two molecules of TAZ bind to and bridge two molecules of TEAD4. We validated the latter using cross-linking and multi-angle light scattering. Using siRNA, we showed that TAZ knockdown leads to a decrease in TEAD4 dimerization. Lastly, results from luciferase assays, using YAP/TAZ transfected or knockdown cells, give support to the non-redundancy of YAP/TAZ co-activators in regulating gene expression in the Hippo pathway. Twit Text FOAVip Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28515457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28515457 #FOAvip English Wikipedia <ref>{{Cite pmid|28515457 }}</ref> Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex #MMPMID28515457 Kaan HYK ; Chan SW ; Tan SKJ ; Guo F ; Lim CJ ; Hong W ; Song H Sci Rep 2017[May]; 7 (1 ): 2035 PMID28515457 show ga The Hippo pathway is a tumor suppressor pathway that is implicated in the regulation of organ size. The pathway has three components: the upstream regulatory factors, the kinase core, and the downstream transcriptional machinery, which consists of YAP, TAZ (transcription co-activators) and TEAD (transcription factor). Formation of YAP/TAZ-TEAD complexes leads to the transcription of growth-promoting genes. Herein, we report the crystal structure of TAZ-TEAD4 complex, which reveals two binding modes. The first is similar to the published YAP-TEAD structure. The second is a unique binding mode, whereby two molecules of TAZ bind to and bridge two molecules of TEAD4. We validated the latter using cross-linking and multi-angle light scattering. Using siRNA, we showed that TAZ knockdown leads to a decrease in TEAD4 dimerization. Lastly, results from luciferase assays, using YAP/TAZ transfected or knockdown cells, give support to the non-redundancy of YAP/TAZ co-activators in regulating gene expression in the Hippo pathway. |*Models, Molecular [MESH] |*Protein Conformation [MESH] |Acyltransferases [MESH] |Adaptor Proteins, Signal Transducing/*chemistry/metabolism [MESH] |Animals [MESH] |Binding Sites [MESH] |Cell Cycle Proteins [MESH] |DNA-Binding Proteins/*chemistry/metabolism [MESH] |Mice [MESH] |Muscle Proteins/*chemistry/metabolism [MESH] |Phosphoproteins/*chemistry/metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Protein Multimerization [MESH] |Recombinant Fusion Proteins [MESH] |Structure-Activity Relationship [MESH] |TEA Domain Transcription Factors [MESH] |Transcription Factors/*chemistry/metabolism [MESH]Crystal structure of TAZ-TEAD complex reveals a distinct interaction m(epmc).pdf DeepDyve Pubget Overpricing