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10.7554/eLife.24284 http://scihub22266oqcxt.onion/10.7554/eLife.24284 C5435464!5435464!28440220     free     free     free       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28440220|t=2017. Rapid evolution of the human mutation spectrum |pdf=|usr=}}{{28440220}} gab.com Text Rapid evolution of the human mutation spectrum JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28440220 #FOAvip DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational spectra differ substantially among species, human continental groups and even some closely related populations. Close examination of one signal, an increased TCC?TTC mutation rate in Europeans, indicates a burst of mutations from about 15,000 to 2000 years ago, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate. Our results suggest that mutation rates can evolve markedly over short evolutionary timescales and suggest the possibility of mapping mutational modifiers.DOI:http://dx.doi.org/10.7554/eLife.24284.001 Twit Text FOAVip Rapid evolution of the human mutation spectrum ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28440220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28440220 #FOAvip English Wikipedia <ref>{{Cite pmid|28440220}}</ref> Rapid evolution of the human mutation spectrum #MMPMID28440220 Harris K; Pritchard JK eLife 2017[]; 6 (ä): ä PMID28440220show ga DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational spectra differ substantially among species, human continental groups and even some closely related populations. Close examination of one signal, an increased TCC?TTC mutation rate in Europeans, indicates a burst of mutations from about 15,000 to 2000 years ago, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate. Our results suggest that mutation rates can evolve markedly over short evolutionary timescales and suggest the possibility of mapping mutational modifiers.DOI:http://dx.doi.org/10.7554/eLife.24284.001 äRapid evolution of the human mutation spectrum (epmc).pdf DeepDyve Pubget Overpricing