Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.devcel.2017.02.009 http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.02.009 C5435110!5435110!28292428     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2017 ; 40 (5): 505-511.e6 Nephropedia Template TP {{tp|p=28292428|t=2017. Cell-cell contact area affects Notch signaling and Notch-dependent patterning |pdf=|usr=}}{{28292428}} gab.com Text Cell-cell contact area affects Notch signaling and Notch-dependent patterning JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28292428 #FOAvip During development, cells undergo dramatic changes in their morphology. By affecting contact geometry, these morphological changes could influence cellular communication. However, it has remained unclear whether and how signaling depends on contact geometry. This question is particularly relevant for Notch signaling, which coordinates neighboring cell fates through direct cell-cell signaling. Using micropatterning with a receptor trans-endocytosis assay, we show that signaling between pairs of cells correlates with their contact area. This relationship extends across contact diameters ranging from microns to tens of microns. Mathematical modeling predicts that dependence of signaling on contact area can bias cellular differentiation in Notch-mediated lateral inhibition processes, such that smaller cells are more likely to differentiate into signal-producing cells. Consistent with this prediction, analysis of developing chick inner ear revealed that ligand-producing hair cell precursors have smaller apical footprints than non-hair cells. Together, these results highlight the influence of cell morphology on fate determination processes. Twit Text FOAVip Cell-cell contact area affects Notch signaling and Notch-dependent patterning ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28292428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28292428 #FOAvip English Wikipedia <ref>{{Cite pmid|28292428}}</ref> Cell-cell contact area affects Notch signaling and Notch-dependent patterning #MMPMID28292428 Shaya O; Binshtok U; Hersch M; Rivkin D; Weinreb S; Amir-Zilberstein L; Khamaisi B; Oppenheim O; Desai RA; Goodyear RJ; Richardson GP; Chen CS; Sprinzak D Dev Cell 2017[Mar]; 40 (5): 505-511.e6 PMID28292428show ga During development, cells undergo dramatic changes in their morphology. By affecting contact geometry, these morphological changes could influence cellular communication. However, it has remained unclear whether and how signaling depends on contact geometry. This question is particularly relevant for Notch signaling, which coordinates neighboring cell fates through direct cell-cell signaling. Using micropatterning with a receptor trans-endocytosis assay, we show that signaling between pairs of cells correlates with their contact area. This relationship extends across contact diameters ranging from microns to tens of microns. Mathematical modeling predicts that dependence of signaling on contact area can bias cellular differentiation in Notch-mediated lateral inhibition processes, such that smaller cells are more likely to differentiate into signal-producing cells. Consistent with this prediction, analysis of developing chick inner ear revealed that ligand-producing hair cell precursors have smaller apical footprints than non-hair cells. Together, these results highlight the influence of cell morphology on fate determination processes. äCell-cell contact area affects Notch signaling and Notch-dependent pat(epmc).pdf DeepDyve Pubget Overpricing