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10.1111/ajt.14082 http://scihub22266oqcxt.onion/10.1111/ajt.14082 C5434819!5434819!27743494     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2017 ; 17 (5): 1160-6 Nephropedia Template TP {{tp|p=27743494|t=2017. Urinary MicroRNA as Biomarker in Renal Transplantation |pdf=|usr=}}{{27743494}} gab.com Text Urinary MicroRNA as Biomarker in Renal Transplantation JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=27743494 #FOAvip Urine represents a noninvasive source in which proteins and nucleic acids can be assessed. Such analytes may function as biomarkers to monitor kidney graft pathology at every desired frequency, thereby providing a time window to prevent graft damage by therapeutic intervention. Recently, several proteins have been measured in urine as markers of graft injury. However, the specificity is limited, and measuring urinary proteins generally lacks the potential to predict early kidney graft damage. Currently, urinary mRNA and microRNA are being investigated to evaluate the prognostic value of changes in gene expression during the initial stages of graft damage. At such time point, a change in treatment regimen and dosage is expected to have maximum potency to minimize future decline in graft function. Both mRNA and microRNAs have shown promising results in both detection and prediction of graft injury. An advantage of microRNAs compared to mRNA molecules is their stability, a characteristic that is beneficial when working with urine samples. In this review, we provide the current state of urinary biomarkers in renal transplantation, with a focus on urinary microRNA. In addition, we discuss the methods used to study urinary microRNA expression. Twit Text FOAVip Urinary MicroRNA as Biomarker in Renal Transplantation ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=27743494 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27743494 #FOAvip English Wikipedia <ref>{{Cite pmid|27743494}}</ref> Urinary MicroRNA as Biomarker in Renal Transplantation #MMPMID27743494 van de Vrie M; Deegens JK; Eikmans M; van der Vlag J; Hilbrands LB Am J Transplant 2017[May]; 17 (5): 1160-6 PMID27743494show ga Urine represents a noninvasive source in which proteins and nucleic acids can be assessed. Such analytes may function as biomarkers to monitor kidney graft pathology at every desired frequency, thereby providing a time window to prevent graft damage by therapeutic intervention. Recently, several proteins have been measured in urine as markers of graft injury. However, the specificity is limited, and measuring urinary proteins generally lacks the potential to predict early kidney graft damage. Currently, urinary mRNA and microRNA are being investigated to evaluate the prognostic value of changes in gene expression during the initial stages of graft damage. At such time point, a change in treatment regimen and dosage is expected to have maximum potency to minimize future decline in graft function. Both mRNA and microRNAs have shown promising results in both detection and prediction of graft injury. An advantage of microRNAs compared to mRNA molecules is their stability, a characteristic that is beneficial when working with urine samples. In this review, we provide the current state of urinary biomarkers in renal transplantation, with a focus on urinary microRNA. In addition, we discuss the methods used to study urinary microRNA expression. äUrinary MicroRNA as Biomarker in Renal Transplantation (epmc).pdf DeepDyve Pubget Overpricing